Overview
| Uniprot ID | A0A8I6AEC6 |
|---|
| Protein Name | Tricarboxylate transport protein, mitochondrial |
|---|
| Gene Name | Slc25a1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 254 |
DCGVQILKNEGPKAF |
Function
Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes
Protein Sequence
10
MAAPRAPRAL
20
TAAAPGSGKA
30
KLTHPGKAIL
40
AGGLAGGIEI
50
CITFPTEYVK
60
TQLQLDERAN
70
PPRYRGIGDC
80
VRQTVRSHGV
90
LGLYRGLSSL
100
LYGSIPKAAV
110
RFGMFEFLSN
120
HMRDAQGRLD
130
SRRGLLCGLG
140
AGVAEAVVVV
150
CPMETVKVKF
160
IHDQTSSNPK
170
YRGFFHGVRE
180
IVREQGLKGT
190
YQGLTATVLK
200
QGSNQAIRFF
210
VMTSLRNWYQ
220
GKSVAQRHIP
230
NPEGWLDAGG
240
GGRHLGLEAH
250
KYRNTLDCGV
260
QILKNEGPKA
270
FYKGTVPRLG
280
RVCLDVAIVF
290
VIYDEVVKLL
NKVWKTD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.