Search Results

Overview

Uniprot ID	A0A8I6AEE8
Protein Name	Epidermal growth factor receptor substrate 15-like 1
Gene Name	Eps15l1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
398	IAQLQREKYSLEQDI
544	DINQARSKLSQLQES

Function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Protein Sequence

10 MAAPLLPLSQ 20 QIPSGNPLYE 30 SYYKQVDPAY 40 TGRVGASEAA 50 LFLKKSGLSD 60 IVLGKIWDLA 70 DPEGKGFLDK 80 QGFYVALRLV 90 ACAQSGHEVT 100 LSNLGLTMPP 110 PKFHDTSSPL 120 MATQSSAEAH 130 WAVEEKAKFD 140 GIFESLLPVN 150 GLLSGDKVKP 160 VLMNSKLPLD 170 VLGRVWDLSD 180 IDKDGHLDRD 190 EFAVAMHLVY 200 RALEKEPVPS 210 VLPPPLIPPS 220 KRKKTVFAGA 230 VPVLPASPPP 240 KDSLRSTPSH 250 GSVSSLNSTG 260 SLSPKHSVKQ 270 TQPPVAWVVP 280 VADKMRFDEI 290 FLKTDLDLDG 300 YVSGQEVKEI 310 FMHSGLTQNL 320 LAHIWALADT 330 RQTGKLSKEQ 340 FALAMYFIQQ 350 KVSKGIDPPQ 360 VLSPDMVPPS 370 ERGTPIPDSS 380 SALGSGEFTG 390 VKELDDISQE 400 IAQLQREKYS 410 LEQDIREKEE 420 AIRQKASEVQ 430 ELQNDLDRET 440 SSLQELEAQK 450 QDAQDRLDEM 460 DQQKAKLRDM 470 LSDVRQKCQD 480 ETQTISSLKT 490 QIQSQESDLK 500 SQEDDLNRAK 510 SELNRLQQEE 520 TQLEQSIQAG 530 RAQLETILRS 540 LKCTQDDINQ 550 ARSKLSQLQE 560 SHLEAHRSLE 570 QYDQVPDGVS 580 GTSLPDLATL 590 NEGILLAERG 600 GFGAMDDPFK 610 NKALLFSNNS 620 QELHPDPFQA 630 EDPFKSDPFK 640 GADPFKGDPF 650 QSDPFSEQQT 660 AVTDPFGGDP 670 FKESDPFHSS 680 TSDDFFKKQT 690 KNDPFTSDPF 700 TKNPSLPSKL 710 DPFESSDPFS 720 SSSISSKGSD 730 PFGTLDPFGS 740 SSFSSAEGFA 750 DFSQMSKPPP 760 SGPFSSSLGG 770 TGFSDDPFKS 780 KQDTPALPPK 790 KPAPPRPKPP 800 SGHLAMRSSS 810 WPGPNGRVRK 820 RSRSGWRGFG 830 DRNRRTWSWP 840 SPSARPICRP R

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030132	clathrin coat of coated pit
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005509	calcium ion binding
Biological Process	GO:0006897	endocytosis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.