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Overview

Uniprot ID	A0A8I6AEZ5
Protein Name	CLIP-associating protein 1
Gene Name	Clasp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
286	MASSLGSKSSAAKEG

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMESCLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVVLLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGICLC 160 LIATLNASGA 170 QTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMIQSANDKN 250 FDDEDSVDGN 260 RPSSASSSSS 270 KAPSSSRRNV 280 SMGTTRRLMA 290 SSLGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIVSLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTASR 590 GSTVSTKSMS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVSSSSGS 630 TAFSSAAALP 640 PGSYASLDGT 650 ATKAEGRIRT 660 RRQSSGSTTN 670 VASTSSDSRG 680 RSRAKVVSQS 690 QRSRSANPAG 700 AGSRSSSPGK 710 LLGSGYGGLA 720 GGSSRGPPVT 730 PSSEKRSKIP 740 RSQGCSRETS 750 PNRIGLARSS 760 RIPRPSMSQG 770 CSRDTSRESS 780 RDTSPARGFT 790 PLASRRHSRS 800 TSALSTAESV 810 GQSDRFGLGQ 820 SGRIPGSVSA 830 MRVLSTSTDL 840 EAAVADALLL 850 GDARSKKKPV 860 RRRYEPYGMY 870 SDDDANSDAS 880 SVCSERSYGS 890 RNGGIPHYLR 900 QTEDVAEVLN 910 HCASSNWSER 920 KEGLLGLQNL 930 LKSQRTLSRV 940 ELKRLCEIFT 950 RMFADPHSKR 960 VFSMFLETLV 970 DFIIIHKDDL 980 QDWLFVLLTQ 990 LLKKMGADLL 1000 GSVQAKVQKA 1010 LDVTRDSFPF 1020 DQQFNILMRF 1030 IVDQTQTPNL 1040 KVKVAILKYI 1050 ESLARQMDPT 1060 DFVNSSETRL 1070 AVSRIITWTT 1080 EPKSSDVRKA 1090 AQIVLISLFE 1100 LNTPEFTMLL 1110 GALPKTFQDG 1120 ATKLLHNHLK 1130 NSSNAGVGSP 1140 SNTIGRTPSR 1150 HPSSRTSPLT 1160 SPTNCSHGGL 1170 SPSRLWGWSA 1180 DGLSKPPPPF 1190 SQPNSIPTAP 1200 SHKTLRRSYS 1210 PSMLDYDTEN 1220 LNSEEIYSSL 1230 RGVTEAIEKF 1240 SFRSQEDLNE 1250 PIKRDGKKDC 1260 DIVSRDGGAA 1270 SPATEGRGGS 1280 EVEGGRMALD 1290 NKTSLLNTQP 1300 PRAFPGPRAR 1310 EYNPYPYSDT 1320 INTYDKTALK 1330 EAVFDDDMEQ 1340 LRDVPIDHSD 1350 LVADLLKELS 1360 NHNERVEERK 1370 GALLELLKIT 1380 REDSLGVWEE 1390 HFKTILLLLL 1400 ETLGDKDHSI 1410 RALALRVLRE 1420 ILRNQPARFK 1430 NYAELTIMKT 1440 LEAHKDSHKE 1450 VVRAAEEAAS 1460 TLASSIHPEQ 1470 CIKVLCPIIQ 1480 TADYPINLAA 1490 IKMQTKVVER 1500 ITKESLLQLL 1510 VDIIPGLLQG 1520 YDNTESSVRK 1530 ASVFCLVAIY 1540 SVIGEDLKPH 1550 LAQLTGSKMK 1560 LLNLYIKRAQ 1570 TTNSNSSSSS DVSTHS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0051494	negative regulation of cytoskeleton organization
Biological Process	GO:1902904	negative regulation of supramolecular fiber organization
Biological Process	GO:0031110	regulation of microtubule polymerization or depolymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.