Overview
| Uniprot ID | A0A8I6AG02 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | Capzb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 111 |
MPSARLRKLEVEANN |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MEQWYFSMSP
20
LAMLCRQSDQ
30
QLDCALDLMR
40
RLPPQQIEKN
50
LSDLIDLVPS
60
LCEDLLSSVD
70
QPLKIARDKV
80
VGKDYLLCDY
90
NRDGDSYRSP
100
WSNKYDPPLE
110
DGAMPSARLR
120
KLEVEANNAF
130
DQYRDLYFEG
140
GVSSVYLWDL
150
DHGFAGVILI
160
KKAGDGSKKI
170
KGCWDSIHVV
180
EVQEKSSGRT
190
AHYKLTSTVM
200
LWLQTNKSGS
210
GTMNLGGSLT
220
RQMEKDETVS
230
DCSPHIANIG
240
RLVEDMENKI
250
RSTLNEIYFG
260
KTKDIVNGLR
270
SVQTFADKSK
280
QEALKNDLVE
ALKRKQQC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.