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Overview

Uniprot ID	A0A8I6AG50
Protein Name	Cytosol aminopeptidase
Gene Name	Lap3
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
221	RFAEVIEKNLKSASS

Function

Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status

Protein Sequence

10 MYLLPLPAAA 20 RVALRRLGVR 30 GLWDRGLSTA 40 DMTKGLVLGI 50 YSKDKDDDVP 60 QFTSAGENFN 70 KLVSGRLREM 80 LNISGPPLKA 90 GKTRTFYGLH 100 QDFPSVVVVG 110 LGKRSAGVDD 120 QENWHEGKEN 130 IRAAVAAGCR 140 QVQDLELPSV 150 EVDPCGDAQA 160 AAEGAVLGLY 170 EYDDLKQKKK 180 VAVSAKLHGS 190 GDLEAWEKGV 200 LFASGQNLAR 210 QLMESPANEM 220 TPTRFAEVIE 230 KNLKSASSKT 240 EVHIRTKSWI 250 EEQEMGSFLS 260 VAKGSEEPPV 270 FLEIHYTGSP 280 NATEAPLVFV 290 GKGITFDSGG 300 ISIKASANMD 310 LMRADMGGAA 320 TICSAIVSAA 330 KLNLPINIIG 340 LAPLCENMPS 350 GKANKPGDVV 360 RARNGKTIQV 370 CEGTTKQPHV 380 DPSSCAMDVA 390 LGSGATGVFT 400 NSSWLWNKLF 410 EASVETGDRV 420 WRMPLFEHYT 430 RQVIDCQLAD 440 VNNLGKYRSA 450 GACTAAAFLR 460 EFVTHTKWAH 470 LDIAGVMTNK 480 DEIPYLRKGM 490 SGRPTRTLIE 500 FLLRFSKDSS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0030145	manganese ion binding
Molecular Function	GO:0070006	metalloaminopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.