Overview
| Uniprot ID | A0A8I6AGV7 |
|---|
| Protein Name | Ubiquitin-like modifier-activating enzyme ATG7 |
|---|
| Gene Name | Atg7 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 305 |
VGWEKNQKGGMGPRM |
Function
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress
Protein Sequence
10
MGDPGLSKLQ
20
FAPFNSALDV
30
GFWHELTQKK
40
LNEYRLDEAP
50
KDIKGYYYNG
60
DSAGLPTRLT
70
LEFSAFDMSA
80
PTPARCCPAM
90
GTLHNTNTLE
100
AFKTADKKLL
110
LEQSANEIWE
120
AIKSGAALEN
130
PMLLNKFLLL
140
TFADLKKYHF
150
YYWFCCPALC
160
LPESIPLIRG
170
PVGLDQRLSP
180
KQIQALEHAY
190
DDLCRTEGVT
200
ALPYFLFKYD
210
DDTVLVSLLK
220
HYSDFFQGQR
230
TKLTVGVYDP
240
CNLTQHPGWP
250
LRNFLVLAAH
260
RWSGSFQSVE
270
VLCFRDRTMQ
280
GARDVTHSII
290
FEVKLPEMAF
300
SPDCPKAVGW
310
EKNQKGGMGP
320
RMVNLSGCMD
330
PKRLAESSVD
340
LNLKLMCWRL
350
VPTLDLDKVV
360
SVKCLLLGAG
370
TLGCNVARTL
380
MGWGVRHVTF
390
VDNAKISYSN
400
PVRQPLYEFE
410
DCLGGGKPKA
420
LAAAERLQKI
430
FPGVNASGFN
440
MSIPMPGHPV
450
NFSDVTMEQA
460
RRDVEQLEEL
470
IDSHDVIFLL
480
MDTRESRWLP
490
TVIAASKRKL
500
VINAALGFDT
510
FVVMRHGLKK
520
PKQQGAGDLC
530
PSHLVAPADL
540
GSSLFANIPG
550
YKLGCYFCND
560
VVAPGDSTRD
570
RTLDQQCTVS
580
RPGLAVIAGA
590
LAVELMVSVL
600
QHPEGGYAIA
610
SSSDDRMNEP
620
PTSLGLVPHQ
630
IRGFLSRFDN
640
VLPVSLAFDK
650
CTACSSKVLD
660
QYEQEGFTFL
670
AKVFNSSHSF
680
LEDLTGLTLL
690
HQETQAAEGL
700
FKMESVRQSL
GTE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000407 |
phagophore assembly site |
| Molecular Function |
GO:0008641 |
ubiquitin-like modifier activating enzyme activity |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
| Biological Process |
GO:0009896 |
positive regulation of catabolic process |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0060255 |
regulation of macromolecule metabolic process |
| Biological Process |
GO:0080090 |
regulation of primary metabolic process |
| Biological Process |
GO:0031667 |
response to nutrient levels |
| Biological Process |
GO:0048511 |
rhythmic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.