Overview
| Uniprot ID | A0A8I6AGZ0 |
| Protein Name | Clathrin heavy chain |
| Gene Name | Cltc |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1074 |
EAFAIFRKFDVNTSA |
| 1118 |
LAKAQLQKGMVKEAI |
| 1122 |
QLQKGMVKEAIDSYI |
| 1209 |
GDRCYDEKMYDAAKL |
| 1254 |
ANSTRTWKEVCFACV |
| 1264 |
CFACVDGKEFRLAQM |
| 1347 |
WSRVNIPKVLRAAEQ |
| 1501 |
SLAQRLEKHELIEFR |
| 1516 |
RIAAYLFKGNNRWKQ |
| 1535 |
CKKDSLYKDAMQYAS |
| 1619 |
AIKEKVDKLDASESL |
| 227 |
VRGQAGGKLHIIEVG |
| 367 |
AEELFARKFNALFAQ |
| 382 |
GNYSEAAKVAANAPK |
| 389 |
KVAANAPKGILRTPD |
| 456 |
EKWLKEDKLECSEEL |
| 506 |
QKIVLYAKKVGYTPD |
| 507 |
KIVLYAKKVGYTPDW |
| 619 |
HIAQLCEKAGLLQRA |
| 637 |
FTDLYDIKRAVVHTH |
| 737 |
KYIQAACKTGQIKEV |
| 742 |
ACKTGQIKEVERICR |
| 78 |
AIMNPASKVIALKAG |
| 806 |
YIEIYVQKVNPSRLP |
| 83 |
ASKVIALKAGKTLQI |
| 851 |
ELVAEVEKRNRLKLL |
| 907 |
YDSRVVGKYCEKRDP |
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating
Protein Sequence
10
MAQILPIRFQ
20
EHLQLQNLGI
30
NPANIGFSTL
40
TMESDKFICI
50
REKVGEQAQV
60
VIIDMNDPSN
70
PIRRPISADS
80
AIMNPASKVI
90
ALKAGKTLQI
100
FNIEMKSKMK
110
AHTMTDDVTF
120
WKWISLNTVA
130
LVTDNAVYHW
140
SMEGESQPVK
150
MFDRHSSLAG
160
CQIINYRTDA
170
KQKWLLLTGI
180
SAQQNRVVGA
190
MQLYSVDRKV
200
SQPIEGHAAS
210
FAQFKMEGNA
220
EESTLFCFAV
230
RGQAGGKLHI
240
IEVGTPPTGN
250
QPFPKKAVDV
260
FFPPEAQNDF
270
PVAMQISEKH
280
DVVFLITKYG
290
YIHLYDLETG
300
TCIYMNRISG
310
ETIFVTAPHE
320
ATAGIIGVNR
330
KGQVLSVCVE
340
EENIIPYITN
350
VLQNPDLALR
360
MAVRNNLAGA
370
EELFARKFNA
380
LFAQGNYSEA
390
AKVAANAPKG
400
ILRTPDTIRR
410
FQSVPAQPGQ
420
TSPLLQYFGI
430
LLDQGQLNKY
440
ESLELCRPVL
450
QQGRKQLLEK
460
WLKEDKLECS
470
EELGDLVKSV
480
DPTLALSVYL
490
RANVPNKVIQ
500
CFAETGQVQK
510
IVLYAKKVGY
520
TPDWIFLLRN
530
VMRISPDQGQ
540
QFAQMLVQDE
550
EPLADITQIV
560
DVFMEYNLIQ
570
QCTAFLLDAL
580
KNNRPSEGPL
590
QTRLLEMNLM
600
HAPQVADAIL
610
GNQMFTHYDR
620
AHIAQLCEKA
630
GLLQRALEHF
640
TDLYDIKRAV
650
VHTHLLNPEW
660
LVNYFGSLSV
670
EDSLECLRAM
680
LSANIRQNLQ
690
ICVQVASKYH
700
EQLSTQSLIE
710
LFESFKSFEG
720
LFYFLGSIVN
730
FSQDPDVHFK
740
YIQAACKTGQ
750
IKEVERICRE
760
SNCYDPERVK
770
NFLKEAKLTD
780
QLPLIIVCDR
790
FDFVHDLVLY
800
LYRNSLQKYI
810
EIYVQKVNPS
820
RLPVVIGGLL
830
DVDCSEDVIK
840
NLILVVRGQF
850
STDELVAEVE
860
KRNRLKLLLP
870
WLEARIHEGC
880
EEPATHNALA
890
KIYIDSNNNP
900
ERFLRENPYY
910
DSRVVGKYCE
920
KRDPHLACVA
930
YERGQCDLEL
940
INVCNENSLF
950
KSLSRYLVRR
960
KDPELWGSVL
970
LESNPYRRPL
980
IDQVVQTALS
990
ETQDPEEVSV
1000
TVKAFMTADL
1010
PNELIELLEK
1020
IVLDNSVFSE
1030
HRNLQNLLIL
1040
TAIKADRTRV
1050
MEYINRLDNY
1060
DAPDIANIAI
1070
SNELFEEAFA
1080
IFRKFDVNTS
1090
AVQVLIEHIG
1100
NLDRAYEFAE
1110
RCNEPAVWSQ
1120
LAKAQLQKGM
1130
VKEAIDSYIK
1140
ADDPSSYMEV
1150
VQAANTSGNW
1160
EELVKYLQMA
1170
RKKARESYVE
1180
TELIFALAKT
1190
NRLAELEEFI
1200
NGPNNAHIQQ
1210
VGDRCYDEKM
1220
YDAAKLLYNN
1230
VSNFGRLAST
1240
LVHLGEYQAA
1250
VDGARKANST
1260
RTWKEVCFAC
1270
VDGKEFRLAQ
1280
MCGLHIVVHA
1290
DELEELINYY
1300
QDRGYFEELI
1310
TMLEAALGLE
1320
RAHMGMFTEL
1330
AILYSKFKPQ
1340
KMREHLELFW
1350
SRVNIPKVLR
1360
AAEQAHLWAE
1370
LVFLYDKYEE
1380
YDNAIITMMN
1390
HPTDAWKEGQ
1400
FKDIITKVAN
1410
VELYYKAIQF
1420
YLEFKPLLLN
1430
DLLMVLSPRL
1440
DHTRAVNYFS
1450
KVKQLPLVKP
1460
YLRSVQNHNN
1470
KSVNESLNNL
1480
FITEEDYQAL
1490
RTSIDAYDNF
1500
DNISLAQRLE
1510
KHELIEFRRI
1520
AAYLFKGNNR
1530
WKQSVELCKK
1540
DSLYKDAMQY
1550
ASESKDTELA
1560
EELLQWFLQE
1570
EKRECFGACL
1580
FTCYDLLRPD
1590
VVLETAWRHN
1600
IMDFAMPYFI
1610
QVMKEYLTKV
1620
DAIKEKVDKL
1630
DASESLRKEE
1640
EQATETQPIV
1650
YGQPQLMLTA
1660
GPSVAVPPQA
1670
PFGYGYTAPP
1680
YGQPQPGFGY
SM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030132 |
clathrin coat of coated pit |
| Biological Process |
GO:1903077 |
negative regulation of protein localization to plasma membrane |
| Biological Process |
GO:0031623 |
receptor internalization |
| Biological Process |
GO:0060236 |
regulation of mitotic spindle organization |
| Biological Process |
GO:0042147 |
retrograde transport, endosome to Golgi |
| Biological Process |
GO:0033572 |
transferrin transport |
| Cellular Component |
GO:0030130 |
clathrin coat of trans-Golgi network vesicle |
| Cellular Component |
GO:0071439 |
clathrin complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:1990498 |
mitotic spindle microtubule |
| Molecular Function |
GO:0032051 |
clathrin light chain binding |
| Molecular Function |
GO:0097718 |
disordered domain specific binding |
| Molecular Function |
GO:0003725 |
double-stranded RNA binding |
| Molecular Function |
GO:0050750 |
low-density lipoprotein particle receptor binding |
| Molecular Function |
GO:0005198 |
structural molecule activity |
| Molecular Function |
GO:1990381 |
ubiquitin-specific protease binding |
| Biological Process |
GO:0150093 |
amyloid-beta clearance by transcytosis |
| Biological Process |
GO:0048268 |
clathrin coat assembly |
| Biological Process |
GO:0072583 |
clathrin-dependent endocytosis |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:1900126 |
negative regulation of hyaluronan biosynthetic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.