Search Results
Overview
| Uniprot ID | A0A8I6AHY6 |
|---|---|
| Protein Name | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial |
| Gene Name | Suclg2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | ILAGGRGKGVFDSGL |
Function
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MALGFLVKMA
20
SAVAIAAQAG
30
KLLRERSLRP
40
RLLAVRSQAG
50
HLTPRRWLNL
60
QEYQSKKLMS
70
EHGVRVQRFF
80
VASTAKEAQE
90
AAKRLNAKEI
100
VLKAQILAGG
110
RGKGVFDSGL
120
KGGVHLTKDP
130
KVVGQLAQQM
140
IGYNLATKQT
150
PKEGVKVNKV
160
MVAEALDISR
170
ETYLAILMDR
180
SHNGPVLVGS
190
PQGGVDIEEV
200
AASSPELIFK
210
EQIDIFEGIK
220
DSQAQRMAEN
230
LGFLGSLKNQ
240
AADQIKKLYH
250
LFLKIDATQV
260
EVNPFGETPE
270
GQVVCFDAKI
280
NFDDNAEFRQ
290
KDIFAMDDKS
300
ENEPIENEAA
310
RYDLKYIGLD
320
GNIACFVNGA
330
GLAMATCDII
340
FLNGGKPANF
350
LDLGGGVKES
360
QVYQAFKLLT
370
SDPKVEAILV
380
NIFGGIVNCA
390
IIANGITKAC
400
QELELKVPLV
410
VRLEGTNVQE
420
AQNILKSSGL
430
PITSAVDLED
440
AAKKAVASVA
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0019003 | GDP binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006105 | succinate metabolic process |
| Biological Process | GO:0006104 | succinyl-CoA metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.