Overview
| Uniprot ID | A0A8I6AIB2 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | Capzb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 264 |
LNEIYFGKTKDIVNG |
| 281 |
SVQTFADKSKQEALK |
| 283 |
QTFADKSKQEALKND |
| 296 |
NDLVEALKRKQQC** |
| 86 |
ARDKVVGKDYLLCDY |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MALSRKTMCI
20
NQVEQSEGFT
30
WQDGRSEMNS
40
SDQQLDCALD
50
LMRRLPPQQI
60
EKNLSDLIDL
70
VPSLCEDLLS
80
SVDQPLKIAR
90
DKVVGKDYLL
100
CDYNRDGDSY
110
RSPWSNKYDP
120
PLEDGAMPSA
130
RLRKLEVEAN
140
NAFDQYRDLY
150
FEGGVSSVYL
160
WDLDHGFAGV
170
ILIKKAGDGS
180
KKIKGCWDSI
190
HVVEVQEKSS
200
GRTAHYKLTS
210
TVMLWLQTNK
220
SGSGTMNLGG
230
SLTRQMEKDE
240
TVSDCSPHIA
250
NIGRLVEDME
260
NKIRSTLNEI
270
YFGKTKDIVN
280
GLRSVQTFAD
290
KSKQEALKND
300
LVEALKRKQQ
C
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.