Search Results
Overview
| Uniprot ID | A0A8I6AK10 |
|---|---|
| Protein Name | Fascin |
| Gene Name | Fscn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 241 | SGPSGTLKAGKATKV |
| 250 | GKATKVGKDELFALE |
| 399 | HGFIGCRKVTGTLDA |
| 41 | NASASSLKKKQIWTL |
| 471 | KVGGRYLKGDHAGVL |
| 74 | GRYLAADKDGNVTCE |
Function
Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF
Protein Sequence
10
MTANGTAEAV
20
QIQFGLISCG
30
NKYLTAEAFG
40
FKVNASASSL
50
KKKQIWTLEQ
60
PPDEAGSAAV
70
CLRSHLGRYL
80
AADKDGNVTC
90
EREVPDGDCR
100
FLVVAHDDGR
110
WSLQSEAHRR
120
YFGGTEDRLS
130
CFAQSVSPAE
140
KWSVHIAMHP
150
QVNIYSVTRK
160
RYAHLSARPA
170
DEIAVDRDVP
180
WGVDSLITLA
190
FQDQRYSVQT
200
SDHRFLRHDG
210
RLVARPEPAT
220
GFTLEFRSGK
230
VAFRDCEGRY
240
LAPSGPSGTL
250
KAGKATKVGK
260
DELFALEQSC
270
AQVVLQAANE
280
RNVSTRQGMD
290
LSANQDEETD
300
QETFQLEIDR
310
DTRKCAFRTH
320
TGKYWTLTAT
330
GGVQSTASTK
340
NASCYFDIEW
350
CERRITLRAS
360
NGKFVTAKKN
370
GQLAATVETA
380
GDSELFLMKL
390
INRPIIVFRG
400
EHGFIGCRKV
410
TGTLDANRSS
420
YDVFQLEFND
430
GAYNIKDSTG
440
KYWTVGSDSS
450
VTSSSDTPVD
460
FFLEFCDYNK
470
VALKVGGRYL
480
KGDHAGVLKA
490
CAETIDPATL
WEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0031253 | cell projection membrane |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0044393 | microspike |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0007043 | cell-cell junction assembly |
| Biological Process | GO:0035089 | establishment of apical/basal cell polarity |
| Biological Process | GO:0030035 | microspike assembly |
| Biological Process | GO:0030046 | parallel actin filament bundle assembly |
| Biological Process | GO:0090091 | positive regulation of extracellular matrix disassembly |
| Biological Process | GO:0051491 | positive regulation of filopodium assembly |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0071803 | positive regulation of podosome assembly |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0032534 | regulation of microvillus assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.