Search Results
Overview
| Uniprot ID | A0A8I6AKB2 |
|---|---|
| Protein Name | Profilin |
| Gene Name | Pfn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 195 | VHGGLINKKCYEMAS |
| 196 | HGGLINKKCYEMASH |
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR
Protein Sequence
10
MVLYHEWKKT
20
NKQKTMNGRD
30
KGMTLCKLLD
40
ACGHSVHPFA
50
APQEMNLCTR
60
PSPARDPSSS
70
PQSSPSSSAM
80
AGWNAYIDSL
90
MADGTCQDAA
100
IVGYKDSPSV
110
WAAVPGKTFV
120
SITPAEVGVL
130
VGKDRSSFFV
140
NGLTLGGQKC
150
SVIRDSLLQD
160
GEFTMDLRTK
170
STGGAPTFNV
180
TVTMTAKTLV
190
LLMGKEGVHG
200
GLINKKCYEM
ASHLRRSQY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001784 | phosphotyrosine residue binding |
| Molecular Function | GO:0070064 | proline-rich region binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:0030838 | positive regulation of actin filament polymerization |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.