Search Results
Overview
| Uniprot ID | A0A8I6AL00 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial |
| Gene Name | Ndufs8 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 69 | TYKYVNMKAQELDVD |
| 78 | QELDVDMKSATDSAA |
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I
Protein Sequence
10
MFQMYRLSSS
20
VLPRALAQAM
30
RTGRTGGFSW
40
GWGTELPGMK
50
SPLLLAGHLN
60
GQSLHSSAVA
70
ATYKYVNMKA
80
QELDVDMKSA
90
TDSAARILMW
100
TELFRGLGMT
110
LSYLFREPAT
120
INYPFEKGPL
130
SPRFRGEHAL
140
RRYPSGEERC
150
IACKLCEAIC
160
PAQAITIEAE
170
PRADGSRRTT
180
RYDIDMTKCI
190
YCGFCQEACP
200
VDAIVEGPNF
210
EFSTETHEEL
220
LYNKEKLLNN
230
GDKWEAEIAA
NIQADYLYR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Molecular Function | GO:0003954 | NADH dehydrogenase activity |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.