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Overview

Uniprot IDA0A8I6AL62
Protein NameAfadin
Gene NameAfdn
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1741 QGQDVSDKVKASRKL

Function

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions

Protein Sequence

10 DLEFHGVMRF 20 YFQDKAAGNF 30 ATKCIRVSST 40 ATTQDVIETL 50 AEKFRPDMRM 60 LSSPKYSLYE 70 VHVSGERRLD 80 IDEKPLVVQL 90 NWNKDDREGR 100 FVLKNENDAI 110 PAKKAQSNGP 120 EKQEKEGVIQ 130 NFKRTLSKKE 140 KKEKKKREKE 150 ALRQASDKEE 160 RPSQGDDSRE 170 NTCYKADIYD 180 EAVSLLKKCT 190 ILSSGGTLRI 200 YADSLKPNIP 210 YKTILLSTTD 220 PADFAVAESL 230 EKYGLEKENP 240 KDYCIARVML 250 PPGAQHSDER 260 GAKEIILDDD 270 ECPLQIFREW 280 PSDKGILVFQ 290 LKRRPPDYIP 300 KKMKKHVEGK 310 PLKGKDRADG 320 SGYGSALPPE 330 KLPYLVELSP 340 GRRNHFAYYS 350 YHTYEDGSDS 360 RDKPKLYRLQ 370 LSVTEVGTEK 380 FDDNSIQLFG 390 PGIQPHHCDL 400 TNMDGVVTVT 410 PRSMDAETYV 420 DGQRISETTM 430 LQSGMRLQFG 440 TSHVFKFVDP 450 IQDHVLSKRS 460 VDGGLMVKGP 470 RHKPGAVQET 480 TFELGGDIHS 490 GTALPASRST 500 TRLDSDRVSS 510 ASSTAERGMV 520 KPMIRLDQEQ 530 DYRRRESRTQ 540 DAAGPELMLP 550 ASIEFRESSE 560 DSFLSAIINY 570 TNSSTVHFKL 580 SPTYVLYMAC 590 RYVLSSQHRP 600 DISPTERTHK 610 AIAVVNKMVS 620 MMEGVIQEVD 630 QVDQKQKNIA 640 GALAFWMANA 650 SELLNFIKQD 660 RDLSRITLDA 670 QDVLAHLVQM 680 AFKYLVHCLQ 690 SELNNYMPAF 700 LDDPEENSLQ 710 RPKIDDVLHT 720 LTGAMSLLRR 730 CRVNAALTIQ 740 LFSQLFHFIN 750 MWLFNRLVTD 760 PDSGLCSHYW 770 GAIIRQQLGH 780 IEAWAEKQGL 790 ELAADCHLSR 800 IVQATTLLTM 810 DKYVPDDIPN 820 INSTCFKLNS 830 LQLQALLQNY 840 HCAPDEPFIP 850 TDLIENVVAV 860 AENTADELAR 870 SDGRDVQLEE 880 DPDLQLPFLL 890 PEDGYSCDVV 900 RNIPNGLQEF 910 LDPLCQRGFC 920 RLVPHTRSPG 930 TWTIYFEGAD 940 YESHLMRENT 950 ELTQPLRKEP 960 EVITVTLKKQ 970 NGMGLSIVAA 980 KGAGQDKLGI 990 YVKSVVKGGA 1000 ADVDGRLAAG 1010 DQLLSVDGRS 1020 LVGLSQERAA 1030 ELMTRTSSVV 1040 TLEVAKQGAI 1050 YHGLATLLNQ 1060 PSPMMQRKAL 1070 TVPWSSSYHS 1080 SCSALQGRSY 1090 ERRELECFLK 1100 NTLKKVTLLF 1110 TNSTDHRSSP 1120 NVANQPPSPG 1130 GKSPYTSGTA 1140 AKITSVSTGN 1150 LCTEEQTPPP 1160 RPEAYPIPTQ 1170 TYTREYFTFP 1180 ASKSQDRMAP 1190 VQNQWPNYEE 1200 KPHMHTESDH 1210 ASIAIQRVTR 1220 SQEELREEKV 1230 YQLERHRVES 1240 GMDRKCDSDM 1250 WINQSSSVES 1260 STSSQEHLNH 1270 SSKSVTPAST 1280 LTKSGPGRWK 1290 TPAAVLPTPV 1300 AVSQPIRTDL 1310 PPPPPPPPAH 1320 YTSDFDGISM 1330 DLPLPPPPAN 1340 QAAPQSAQVA 1350 AAERKKREEH 1360 QRWYEKEKAR 1370 LEEERERKRR 1380 EQERKLGQMR 1390 TQSLNPASFS 1400 PLATQAKPEK 1410 PSTLQRPQET 1420 VIRELQPQQQ 1430 PRTIERRDLQ 1440 YITISKEELS 1450 SGDSLSPDPW 1460 KRDAREKLEK 1470 QQQMHIVDML 1480 SKEIHELQNK 1490 GDRTAEESDR 1500 LRKLMLEWQF 1510 QKRLQESKQK 1520 DEDDDEEEDD 1530 DVDTMLIMQR 1540 LEAERRARLQ 1550 DEERRRQQQL 1560 EEMRKREVED 1570 RVRQEEDGRH 1580 QEEERVKRDA 1590 EEKRRQEEGY 1600 YSRLEAERRR 1610 QHEEAARRLL 1620 EPEEPGLSRP 1630 PLPQDYEPPS 1640 QSSAPSAPPP 1650 PPQRNASYLK 1660 TQVLSPDSLF 1670 TAKFVAYDDD 1680 DEEENYVPAG 1690 PNSYSGSAGT 1700 TAGTYDAPRD 1710 TREKLSRSQD 1720 ADLPGSSGAP 1730 ENLTFRERQR 1740 LFSQGQDVSD 1750 KVKASRKLTE LENELNTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030154 cell differentiation
Biological Process GO:0034330 cell junction organization
Biological Process GO:0099175 regulation of postsynapse organization
Biological Process GO:0007165 signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.