Search Results
Overview
| Uniprot ID | A0A8I6ALC1 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein A1 |
| Gene Name | Hnrnpa1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | MSKSESPKEPEQLRK |
Function
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins
Protein Sequence
10
MSKSESPKEP
20
EQLRKLFIGG
30
LSFETTDESL
40
RSHFEQWGTL
50
TDCVVMRDPN
60
TKRSRGFGFV
70
TYATVEEVDA
80
AMNARPHKVD
90
GRVVEPKRAV
100
SREDSQRPGA
110
HLTVKKIFVG
120
GIKEDTEEHH
130
LRDYFEQYGK
140
IEVIEIMTDR
150
GSGKKRGFAF
160
VTFDDHDSVD
170
KIVIQKYHTV
180
NGHNCEVRKA
190
LSKQEMASAS
200
SSQRGRSGSG
210
NFGGGRGGGF
220
GGNDNFGRGG
230
NFSGRGGFGG
240
SRGGGGYGGS
250
GDGYNGFGND
260
GSNFGGGGSY
270
NDFGNYNNQS
280
SNFGPMKGGN
290
FGGRSSGPYG
300
GGGQYFAKPR
310
NQGGYGGSSS
320
SSSYGSGRRF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003723 | RNA binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.