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Overview

Uniprot IDA0A8I6ALG2
Protein NameNuclear receptor corepressor 1
Gene NameNcor1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1377 YDGITTIKEMGRSIH

Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver

Protein Sequence

10 MSSSGYPPNQ 20 GAFSTEQSRY 30 PSQSVQYTFP 40 STRHQQEFAV 50 PDYRSSHIEV 60 SQASQLLQQQ 70 QQQQQLRRRP 80 SLLSEFHPGS 90 DRPQERRTGY 100 EQFHSGPSPV 110 DHDSLESKRP 120 RLEPVSDAHF 130 QRVSAAVLPL 140 VHTLPEGLRA 150 SADAKKDSAF 160 GGKHEAPSSP 170 LAGQPCGDDQ 180 NASPSKLSKE 190 ELIQSMDRVD 200 REIAKVEQQI 210 LKLKKKQQQL 220 EEEAAKPPEP 230 EKPVSPPPVE 240 QKHRSIVQII 250 YDENRKKAEE 260 AHKIFEGLGP 270 KVELPLYNQP 280 SDTKVYHENI 290 KTGVPARRMM 300 KNQVMRKKLI 310 LFFKRRNHAR 320 KQREQKICQR 330 YDQLMEAWEK 340 KVDRIENNPR 350 RKAKESKTRE 360 YYEKQFPEIR 370 KQREQQERFQ 380 RVGQRGAGLS 390 ATIARSEHEI 400 SEIIDGLSEQ 410 ENNEKQMRQL 420 SVIPPMMFDA 430 EQRRVKFINM 440 NGLMEDPMKV 450 YKDRQFMNVW 460 TDHEKEIFKD 470 KFIQHPKNFG 480 LIASYLERKS 490 VPDCVLYYYL 500 TKKNENYKAL 510 VRRNYGKRRG 520 RNQQIARPSQ 530 EEKVEEKEED 540 KAEKMEKKEE 550 EKKDDEEKDE 560 KEESKETTKE 570 KDRTEATAEE 580 TEEREQVTPR 590 GRKTANSQGR 600 RKGRITRSMT 610 SEAAAASAAA 620 AATEEPPPPL 630 PPPPEPVSTE 640 PVETSRWTEE 650 EMEVAKKGLV 660 EHGRNWAAIA 670 KMVGTKSEAQ 680 CKNFYFNYKR 690 RHNLDNLLQQ 700 HKQKASRKPR 710 EERDVSQCES 720 VASTVSAQED 730 EDIEASNEEE 740 NPEDSEGAEN 750 SSDTESAPSP 760 SPVEAAKSSE 770 DSSENAASRG 780 NTEPVAELEA 790 TTDPAPCASP 800 SSAVPTTKPA 810 ESESVEAQVT 820 DSASVETAEP 830 MDVDHEECGA 840 QGSSVLDPPA 850 PTKADSVDPE 860 IQVPENTASK 870 GEGDAKDRDL 880 ESASEKTEAR 890 DEDLVVAEQM 900 QRPEPQSDND 910 SSATCSADED 920 VDGEPERQRV 930 FPMDAKPSLL 940 NPPGSILISS 950 PIKPNPLDLP 960 QLQHRAAVIP 970 PMVSCTPCNI 980 PIGTPVSGYA 990 LYQRHIKAMH 1000 ESALLEEQRQ 1010 RQEQIDLECR 1020 SSTSPCGTSK 1030 SPNREWEGKS 1040 VAYMPYAEVK 1050 RALEQEAQMH 1060 STAARSASPC 1070 RLSPREVSKA 1080 ASQPDMSAAR 1090 YSVPPVLQPA 1100 PHQVITNLPE 1110 GVRLPTTRPT 1120 RPPPPLIPSS 1130 KTTVASEKPS 1140 FIMGGSISQG 1150 TPGTYLTSHS 1160 QAYTPEAAKP 1170 SVGSISLGLP 1180 RQQESTKSAP 1190 LTYIKQEEFS 1200 PRSQNSQPEG 1210 LLVRAQHEGV 1220 VRGTAGAVQE 1230 GSITRGTPAS 1240 KISVESISSL 1250 RGSITQGTPA 1260 LPQAGIPTEA 1270 LVKGPVSRMP 1280 IEESSPEKVR 1290 EEAASKGHVI 1300 YEGKSGHILS 1310 YDSLICRALP 1320 RGSPHSDLKE 1330 RTVLSGSIMQ 1340 GTPRATAESF 1350 EDGLKYPKQI 1360 KRESPPSRAF 1370 EGAITKGKPY 1380 DGITTIKEMG 1390 RSIHEIPRQD 1400 ILTQESRKTP 1410 EVVQSTRPII 1420 EGSISQGTPI 1430 KFDNNSGQSA 1440 IKHNVKSLIT 1450 GPSKLPRGML 1460 EIVPENIKVV 1470 ERGKYEDVKA 1480 GEPVRPRHTS 1490 VVSSGPSVLR 1500 STLHEAPKAQ 1510 LSPGIYDDSS 1520 ARRTPVSYQN 1530 TISRGSPMMN 1540 RTSDGSSSKT 1550 TSHERKSALT 1560 PTQRESVPAK 1570 SPVPAVDSVV 1580 SHSPFDPHHR 1590 STTAGEVYRS 1600 HLPTHLDPAM 1610 PFHRALDPAA 1620 AAYLFQRQLS 1630 PTPGYPSQYQ 1640 LYAMENTRQT 1650 ILNDYITSQQ 1660 MQVNLRPDVA 1670 RGLSPREQPL 1680 GLPYPATRGI 1690 IDLTNMPPTI 1700 LVPHAGGTST 1710 PPMDRITYIP 1720 GTQITFPPRP 1730 YNAASLSPGH 1740 PTHLAAAASA 1750 EREREREREK 1760 ERERERERER 1770 ERERERERER 1780 ERERERERIT 1790 AAPTDLYLRP 1800 GSEQPGRPGS 1810 HGYVRSPSPS 1820 VRTQETMLQQ 1830 RPSVFQGTNG 1840 TSVITPLDPT 1850 AQLRIMPLPS 1860 GGPSISQGLP 1870 ASRYNTAADA 1880 LAALVDAAAS 1890 APQMDVSKTK 1900 ESKHEAARLE 1910 DNVRSRSAAV 1920 SEQQQLEQKN 1930 LEVEKRSVQC 1940 VCTSSALPSG 1950 KPQPHASVVY 1960 SEAGKDKGPP 1970 PKSRYEEELR 1980 TRGKTTITAA 1990 NFIDVIITRQ 2000 IASDKDARER 2010 GSQSSDSSSS 2020 LSSHRYEAPS 2030 DAIEVISPAS 2040 SPAPPQEKPQ 2050 AYQPEMVKAN 2060 QAENESPQQY 2070 EGPLHHYRSQ 2080 QGSPSPQQQP 2090 PLPPSSQAEG 2100 MGQVPRTHRL 2110 ITLADHICQI 2120 ITQDFARNQV 2130 PSQPSTSTFQ 2140 TSPSALSSTP 2150 VRTKPSSRYS 2160 PESQSQTVLH 2170 PRPGPRVSPE 2180 NLVDKSRGSR 2190 PGKSPERSHI 2200 PSEPYEPISP 2210 PQGPAVHEKQ 2220 DSMLLLSQRG 2230 MDPAEQRSDS 2240 RSPGSISYLP 2250 SFFTKLESTS 2260 PMVKSKKQEI 2270 FRKLNSSGGG 2280 DSDMAAAQPG 2290 TEIFNLPAVT 2300 TSGAVSSRSH 2310 SFADPASNLG 2320 LEDIIRKALM 2330 GSFDDKVEDH 2340 GVVMPHPVGV 2350 VPGSASTSVV 2360 TSSETRRDEG 2370 DPSPHSGVCK 2380 PKLINKSNSR 2390 KSKSPIPGQN 2400 YLGTERPSSV 2410 SSVHSEGDYH 2420 RQTPGWAWED 2430 RPSSTGSTQF 2440 PYNPLTIRML 2450 SSTPPTPIAC 2460 APSAITQAAP 2470 HQQSRIWERE 2480 PAPLLSAQYE TLSDSDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032991 protein-containing complex

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.