Overview
| Uniprot ID | A0A8I6ALG2 |
| Protein Name | Nuclear receptor corepressor 1 |
| Gene Name | Ncor1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1377 |
YDGITTIKEMGRSIH |
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver
Protein Sequence
10
MSSSGYPPNQ
20
GAFSTEQSRY
30
PSQSVQYTFP
40
STRHQQEFAV
50
PDYRSSHIEV
60
SQASQLLQQQ
70
QQQQQLRRRP
80
SLLSEFHPGS
90
DRPQERRTGY
100
EQFHSGPSPV
110
DHDSLESKRP
120
RLEPVSDAHF
130
QRVSAAVLPL
140
VHTLPEGLRA
150
SADAKKDSAF
160
GGKHEAPSSP
170
LAGQPCGDDQ
180
NASPSKLSKE
190
ELIQSMDRVD
200
REIAKVEQQI
210
LKLKKKQQQL
220
EEEAAKPPEP
230
EKPVSPPPVE
240
QKHRSIVQII
250
YDENRKKAEE
260
AHKIFEGLGP
270
KVELPLYNQP
280
SDTKVYHENI
290
KTGVPARRMM
300
KNQVMRKKLI
310
LFFKRRNHAR
320
KQREQKICQR
330
YDQLMEAWEK
340
KVDRIENNPR
350
RKAKESKTRE
360
YYEKQFPEIR
370
KQREQQERFQ
380
RVGQRGAGLS
390
ATIARSEHEI
400
SEIIDGLSEQ
410
ENNEKQMRQL
420
SVIPPMMFDA
430
EQRRVKFINM
440
NGLMEDPMKV
450
YKDRQFMNVW
460
TDHEKEIFKD
470
KFIQHPKNFG
480
LIASYLERKS
490
VPDCVLYYYL
500
TKKNENYKAL
510
VRRNYGKRRG
520
RNQQIARPSQ
530
EEKVEEKEED
540
KAEKMEKKEE
550
EKKDDEEKDE
560
KEESKETTKE
570
KDRTEATAEE
580
TEEREQVTPR
590
GRKTANSQGR
600
RKGRITRSMT
610
SEAAAASAAA
620
AATEEPPPPL
630
PPPPEPVSTE
640
PVETSRWTEE
650
EMEVAKKGLV
660
EHGRNWAAIA
670
KMVGTKSEAQ
680
CKNFYFNYKR
690
RHNLDNLLQQ
700
HKQKASRKPR
710
EERDVSQCES
720
VASTVSAQED
730
EDIEASNEEE
740
NPEDSEGAEN
750
SSDTESAPSP
760
SPVEAAKSSE
770
DSSENAASRG
780
NTEPVAELEA
790
TTDPAPCASP
800
SSAVPTTKPA
810
ESESVEAQVT
820
DSASVETAEP
830
MDVDHEECGA
840
QGSSVLDPPA
850
PTKADSVDPE
860
IQVPENTASK
870
GEGDAKDRDL
880
ESASEKTEAR
890
DEDLVVAEQM
900
QRPEPQSDND
910
SSATCSADED
920
VDGEPERQRV
930
FPMDAKPSLL
940
NPPGSILISS
950
PIKPNPLDLP
960
QLQHRAAVIP
970
PMVSCTPCNI
980
PIGTPVSGYA
990
LYQRHIKAMH
1000
ESALLEEQRQ
1010
RQEQIDLECR
1020
SSTSPCGTSK
1030
SPNREWEGKS
1040
VAYMPYAEVK
1050
RALEQEAQMH
1060
STAARSASPC
1070
RLSPREVSKA
1080
ASQPDMSAAR
1090
YSVPPVLQPA
1100
PHQVITNLPE
1110
GVRLPTTRPT
1120
RPPPPLIPSS
1130
KTTVASEKPS
1140
FIMGGSISQG
1150
TPGTYLTSHS
1160
QAYTPEAAKP
1170
SVGSISLGLP
1180
RQQESTKSAP
1190
LTYIKQEEFS
1200
PRSQNSQPEG
1210
LLVRAQHEGV
1220
VRGTAGAVQE
1230
GSITRGTPAS
1240
KISVESISSL
1250
RGSITQGTPA
1260
LPQAGIPTEA
1270
LVKGPVSRMP
1280
IEESSPEKVR
1290
EEAASKGHVI
1300
YEGKSGHILS
1310
YDSLICRALP
1320
RGSPHSDLKE
1330
RTVLSGSIMQ
1340
GTPRATAESF
1350
EDGLKYPKQI
1360
KRESPPSRAF
1370
EGAITKGKPY
1380
DGITTIKEMG
1390
RSIHEIPRQD
1400
ILTQESRKTP
1410
EVVQSTRPII
1420
EGSISQGTPI
1430
KFDNNSGQSA
1440
IKHNVKSLIT
1450
GPSKLPRGML
1460
EIVPENIKVV
1470
ERGKYEDVKA
1480
GEPVRPRHTS
1490
VVSSGPSVLR
1500
STLHEAPKAQ
1510
LSPGIYDDSS
1520
ARRTPVSYQN
1530
TISRGSPMMN
1540
RTSDGSSSKT
1550
TSHERKSALT
1560
PTQRESVPAK
1570
SPVPAVDSVV
1580
SHSPFDPHHR
1590
STTAGEVYRS
1600
HLPTHLDPAM
1610
PFHRALDPAA
1620
AAYLFQRQLS
1630
PTPGYPSQYQ
1640
LYAMENTRQT
1650
ILNDYITSQQ
1660
MQVNLRPDVA
1670
RGLSPREQPL
1680
GLPYPATRGI
1690
IDLTNMPPTI
1700
LVPHAGGTST
1710
PPMDRITYIP
1720
GTQITFPPRP
1730
YNAASLSPGH
1740
PTHLAAAASA
1750
EREREREREK
1760
ERERERERER
1770
ERERERERER
1780
ERERERERIT
1790
AAPTDLYLRP
1800
GSEQPGRPGS
1810
HGYVRSPSPS
1820
VRTQETMLQQ
1830
RPSVFQGTNG
1840
TSVITPLDPT
1850
AQLRIMPLPS
1860
GGPSISQGLP
1870
ASRYNTAADA
1880
LAALVDAAAS
1890
APQMDVSKTK
1900
ESKHEAARLE
1910
DNVRSRSAAV
1920
SEQQQLEQKN
1930
LEVEKRSVQC
1940
VCTSSALPSG
1950
KPQPHASVVY
1960
SEAGKDKGPP
1970
PKSRYEEELR
1980
TRGKTTITAA
1990
NFIDVIITRQ
2000
IASDKDARER
2010
GSQSSDSSSS
2020
LSSHRYEAPS
2030
DAIEVISPAS
2040
SPAPPQEKPQ
2050
AYQPEMVKAN
2060
QAENESPQQY
2070
EGPLHHYRSQ
2080
QGSPSPQQQP
2090
PLPPSSQAEG
2100
MGQVPRTHRL
2110
ITLADHICQI
2120
ITQDFARNQV
2130
PSQPSTSTFQ
2140
TSPSALSSTP
2150
VRTKPSSRYS
2160
PESQSQTVLH
2170
PRPGPRVSPE
2180
NLVDKSRGSR
2190
PGKSPERSHI
2200
PSEPYEPISP
2210
PQGPAVHEKQ
2220
DSMLLLSQRG
2230
MDPAEQRSDS
2240
RSPGSISYLP
2250
SFFTKLESTS
2260
PMVKSKKQEI
2270
FRKLNSSGGG
2280
DSDMAAAQPG
2290
TEIFNLPAVT
2300
TSGAVSSRSH
2310
SFADPASNLG
2320
LEDIIRKALM
2330
GSFDDKVEDH
2340
GVVMPHPVGV
2350
VPGSASTSVV
2360
TSSETRRDEG
2370
DPSPHSGVCK
2380
PKLINKSNSR
2390
KSKSPIPGQN
2400
YLGTERPSSV
2410
SSVHSEGDYH
2420
RQTPGWAWED
2430
RPSSTGSTQF
2440
PYNPLTIRML
2450
SSTPPTPIAC
2460
APSAITQAAP
2470
HQQSRIWERE
2480
PAPLLSAQYE
TLSDSDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0032991 |
protein-containing complex |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.