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Overview

Uniprot IDA0A8I6ALH4
Protein NameGeneral transcription factor II-I
Gene NameGtf2i
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
315 VREFNFEKWNARITD

Function

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation

Protein Sequence

10 MAQVAMSALP 20 AEDEESSESR 30 MVVTFLMSAL 40 ESMCKELAKS 50 KAEVACIAVY 60 ETDVFVVGTE 70 RGRAFVNTRK 80 DFQKDFVKYC 90 VEEEEKAAEM 100 HKMKCTTQAN 110 RMSVDAVEIE 120 TLRKTVEDYF 130 CFCYGKALGK 140 STVVPVPYEK 150 MLRDQSAVAV 160 QGLPEGVAFK 170 HPEHYDLATL 180 KWILENKAGI 190 SFIIKRPFLE 200 PKKHLGGRVM 210 AADADRPMLS 220 PGGSCGPIKV 230 KTEPTEDSGI 240 SLEMAAVTVK 250 EESEDPDYYQ 260 YNIQDSTQHV 270 PSETSEDPEV 280 EVTIEDDDYS 290 PPTKRPKSSE 300 PPPPPPVPEP 310 TNAGKRKVRE 320 FNFEKWNARI 330 TDLRKQVEEL 340 FERKYAQAIK 350 AKGPVTIPYP 360 LFQSHVEDLY 370 VEGLPEGIPF 380 RRPSTYGIPR 390 LERILLAKER 400 IRFVIKKHEL 410 LNSTREDLQL 420 DKPASGVKEE 430 WYARITKLRK 440 MVDQLFCKKF 450 AEALGSTEAK 460 AVPYQKFEAY 470 PNDLYVEGLP 480 ENIPFRSPSW 490 YGIPRLEKII 500 QVGNRIKFVI 510 KRPELLTHST 520 TEVTQPRTNT 530 PVKEDWNVRI 540 TKLRKQVEEI 550 FNLKFAQALG 560 LTEAVKVPYP 570 VFESNPEFLY 580 VEGLPEGIPF 590 RSPTWFGIPR 600 LERIVRGSNK 610 IKFVVKKPEL 620 VVSYLPPGMA 630 SKINTKALQS 640 PKRPRSPGSN 650 SKVPEIEVTV 660 EGPNNNSPQT 670 STVRTPTQTN 680 GSNVPFKPRG 690 REFSFEAWNA 700 KITDLKQKVE 710 NLFNEKCGEA 720 LGLKQAVKVP 730 FALFESFPED 740 FYVEGLPEGV 750 PFRRPSTFGI 760 PRLEKILRNK 770 AKIKFIIKKP 780 EMFETAIKES 790 TSSKSPPRKT 800 NSSPSVNTTA 810 SGVEDLNIIQ 820 VTIPDDDNER 830 LSKVEKARQL 840 REQVNDLFSR 850 KFGEAIGMGF 860 PVKVPYRKIT 870 INPGCVVVDG 880 MPPGVSFKAP 890 SYLEISSMRR 900 ILDSAEFIKF 910 TVIRPFPGLV 920 INNQLVDQNE 930 SEGPVIQESA 940 EASQLEVPAT 950 EEIKETDGSS 960 QIKQEPDPTW

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.