Search Results

Overview

Uniprot ID	A0A8I6AM24
Protein Name	AP-3 complex subunit delta-1
Gene Name	Ap3d1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
7	*MALKMVKGSIDRMF
816	SEKLPVQKHRNAETV

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Protein Sequence

10 MALKMVKGSI 20 DRMFDKNLQD 30 LVRGIRNHKE 40 DEAKYISQCI 50 DEIKQELKQD 60 NIAVKANAVC 70 KLTYLQMLGY 80 DISWAAFNII 90 EVMSASKFTF 100 KRVGYLAASQ 110 CFHEGTDVIM 120 LTTNQIRKDL 130 SSPSQYDTGV 140 ALTGLSCFVT 150 PDLARDLAND 160 IMTLMSHTKP 170 YIRKKAVLIM 180 YKVFLKYPES 190 LRPAFPRLKE 200 KLEDPDPGVQ 210 SAAVNVICEL 220 ARRNPKNYLS 230 LAPLFFKLMT 240 SSTNNWVLIK 250 IIKLFGALTP 260 LEPRLGKKLI 270 EPLTNLIHST 280 SAMSLLYECV 290 NTVIAVLISL 300 SSGMPNHSAS 310 IQLCVQKLRI 320 LIEDSDQNLK 330 YLGLLAMSKI 340 LKTHPKSVQS 350 HKDLILQCLD 360 DKDESIRLRA 370 LDLLYGMVSK 380 KNLMEIVKKL 390 MTHVDKAEGT 400 TYRDELLTKI 410 IDICSQSNYQ 420 HITNFEWYIS 430 ILVELTRLEG 440 TRHGHLIAAQ 450 MLDVAIRVKA 460 IRKFAVSQMS 470 SLLDSAHLVA 480 SSTQRNGICE 490 VLYAAAWICG 500 EFSEHLQGPQ 510 QTLEAMLRPK 520 VTTLPGHIQA 530 VYVQNVVKLY 540 ASILQQKEQA 550 ADTEGAQEVT 560 QLLVERLPQF 570 VQSADLEVQE 580 RASCILQLVK 590 HVQKLQAKGV 600 PVAEEVSALF 610 AGELNPVAPK 620 AQKKVPVPEG 630 LDLDAWINEP 640 PSDSESEDEK 650 PKAIFHEEEP 660 RHTRRRQPEE 670 DEEELARRRE 680 ARKQEQANNP 690 FYIKSSPSPQ 700 KRYQDAPGVE 710 HIPVVQIDLS 720 VPLKVPGMPM 730 SDQYVKLEEQ 740 RRHRQRLEKD 750 KKRKKKEKGK 760 RRHSSLPTES 770 DEDIAPAQRV 780 DIITEEMPEN 790 ALPSDEDDKD 800 PNDPYRALDI 810 DLDKPLADSE 820 KLPVQKHRNA 830 ETVKSPEKEG 840 VPGVEKKSKK 850 PKKKEKKPKE 860 REREKKDKKE 870 GLAASIVTPP 880 KGECEVLKGE 890 EPQDEEDHMD 900 HDQERKSSRH 910 KKKKHRKEKE 920 ERPRDKKKAK 930 RKQVVQLENG 940 APAEEEEEEE 950 EPIPPMSSYC 960 LLAENPYIKV 970 TYDVQASLQK 980 DSQVTVSIIL 990 ENQSSSFLKN 1000 MELNVLDSLN 1010 TKMARPEGSS 1020 VHDGVPVPFQ 1030 LPPGVSNEAQ 1040 FVFTIQSIVM 1050 AQKLKGTLSF 1060 IAKDDEGATH 1070 EKLDFRLHFS 1080 CSSYLITTPC 1090 YSDAFAKLLE 1100 SGDLSMNSIK 1110 VDGISISFQN 1120 LLAKICFYHH 1130 FSVVERVDSC 1140 ASMYSRSIQG 1150 HHVCLLVKKG 1160 ESSVSVDGKC 1170 SDATLLSSLL 1180 EEMKTTLSQC

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030123	AP-3 adaptor complex
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0000139	Golgi membrane
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0007041	lysosomal transport
Biological Process	GO:0016050	vesicle organization
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.