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Overview

Uniprot IDA0A8I6AMB7
Protein NameSH3-containing GRB2-like protein 3-interacting protein 1
Gene NameSgip1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
126 KIKPLQSKDVLKNAA
130 LQSKDVLKNAATVDE
302 PRPPSRPKLPPGKPG
307 RPKLPPGKPGVGDVS
413 FKGADPSKCIVKITG

Function

May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis

Protein Sequence

10 MMEGLKKRTR 20 KAFGIRKKEK 30 DTDSTGSPDR 40 DGMPSPHEPP 50 YHSKAECARE 60 GGKKASKKSN 70 GAPNGFYAEI 80 DWERYNSPEL 90 DEEGYSIRPE 100 EPGSTKGKHF 110 YSSSESEEEE 120 ESHKKFNIKI 130 KPLQSKDVLK 140 NAATVDELKA 150 SIGNIALSPS 160 PVRKSPRRSP 170 GAIKRNLSSE 180 EVARPRRSTP 190 TPELTSKKPL 200 DDTLALAPLF 210 GPPLESAFDE 220 QKTEVLLDQP 230 EIWGSGQPIN 240 PSMESPKLAR 250 PFPTGTPPPL 260 PPKAVPATPP 270 RTGSPLTVAT 280 GASSPARPAT 290 PLVPCSSTTP 300 PPPPPRPPSR 310 PKLPPGKPGV 320 GDVSRPFSPP 330 IHSSSPPPIA 340 PLARAESTSS 350 ISSTNSLSAA 360 TTPTVENEQP 370 SLVWFDRGKF 380 YLTFEGSSRG 390 PSPLTMGAQD 400 TLPVAAAFTE 410 TVNAYFKGAD 420 PSKCIVKITG 430 EMVLSFPAGI 440 TRHFANNPSP 450 AALTFRVINS 460 SRLEHVLPNP 470 QLLCCDNTQN 480 DANTKEFWVN 490 MPNLMTHLKK 500 VSEQKPQATY 510 YNVDMLKYQV 520 SAQGIQSTPL 530 NLAVNWRCEP 540 GSTDLRIDYK 550 YNTDAMTTAV 560 ALNNVQFLVP 570 IDGGVTKLQA 580 VLPPAVWNAE 590 QQRILWKIPD 600 ISQKSENGGV 610 GSLLARFQLS 620 EGPSKPSPLV 630 VQFTSEGSTL 640 SGCDIELVGA 650 GYRFSLIKKR 660 FAAGKYLADN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005905 clathrin-coated pit
Biological Process GO:0072583 clathrin-dependent endocytosis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.