Search Results

Overview

Uniprot ID	A0A8I6AMC6
Protein Name	Kinesin-like protein KIF21A
Gene Name	Kif21a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
562	KKKSVAGKENNADPD
832	QVRPMSDKVAGKVTR

Function

Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex

Protein Sequence

10 MLGAADESSV 20 RVAVRIRPQL 30 AKEKIEGCHI 40 CTSVTPGEPQ 50 VFLGKDKAFT 60 FDYVFDIDSQ 70 QEQIYTQCIE 80 KLIEGCFEGY 90 NATVFAYGQT 100 GAGKTYTMGT 110 GFDVNIMEEE 120 QGIISRAVKH 130 LFKSIEEKKT 140 SAIKNGVPPP 150 EFKVNAQFLE 160 LYNEEVLDLF 170 DTTRDIDAKN 180 KKSNIRIHED 190 STGGIYTVGV 200 TTRTVNTEPE 210 MMQCLKLGAL 220 SRTTASTQMN 230 VQSSRSHAIF 240 TIHVCQTRVC 250 PQTDAENVTD 260 NKMVSESPQM 270 NEFETLTAKF 280 HFVDLAGSER 290 LKRTGATGER 300 AKEGISINCG 310 LLALGNVISA 320 LGDKSKRATH 330 VPYRDSKLTR 340 LLQDSLGGNS 350 QTIMIACVSP 360 SDRDFMETLN 370 TLKYANRARN 380 IKNKVMVNQD 390 RASQQINALR 400 SEITRLQMEL 410 MEYKTGKRII 420 DEEGVESIND 430 MFHENAMLQT 440 ENNNLRVRIK 450 AMQETVDALR 460 ARITQLVSEQ 470 ANQVLARAGE 480 GNEEISNMIH 490 SYIKEIEDLR 500 AKLLESEAVN 510 ENLRKSLTRA 520 TARSPFFSAS 530 SAFSSTILSS 540 DKETIEIIDL 550 AKKDLEKLKR 560 KEKRKKKSVA 570 GKENNADPDQ 580 EKKEEKGVSE 590 KESSEVDVDE 600 NQEASDHEDE 610 EDEEEEDEEE 620 DDIEGEESSD 630 ESDSESDEKA 640 NYQADLANIT 650 CEIAIKQKLI 660 DELENSQKRL 670 QTLKKQYEEK 680 LMMLQHKIRD 690 TQLERDQVLQ 700 NLGSVESYSE 710 EKAKKVKCEY 720 EKKLHAMNKE 730 LQRLQTAQKE 740 HARLLKNQSQ 750 YEKQLKKLQQ 760 DVTEMKKTKV 770 RLMKQMKEEQ 780 EKARLTESRR 790 NREIAQLKKD 800 QRKRDHQLRL 810 LEAQKRNQEV 820 VLRRKTEEVT 830 ALRRQVRPMS 840 DKVAGKVTRK 850 LSSSESPTPD 860 AGSSVTSGEA 870 DASRPGTQQK 880 MRIPVARVQA 890 LPTPTTNGTR 900 KRYQRKGFTG 910 RVFTSKTARM 920 KWQLLERRVT 930 EIIMQKMTIS 940 NMEADMNRLL 950 RQREELTKRR 960 EKLSKRREKI 970 AKESGEGDKN 980 LVNISEEMES 990 LTANIDYIND 1000 SIADCQANIM 1010 QMEEAKEEGE 1020 TLDVTAVINA 1030 CTLTEARYLL 1040 DHFLSMGINK 1050 GLQAAQKEAQ 1060 IKVLEGRLKQ 1070 TEITSATQNQ 1080 LLFHMLKEKA 1090 ELNPELDALL 1100 GNALQEDEED 1110 SSEEDGPLHS 1120 PGSEGSTLSS 1130 DLMKLCGEVK 1140 PKNKARRRTT 1150 TQMELLYADS 1160 SEVASDTSAG 1170 DASLPGPLTP 1180 VAEGQETGMN 1190 TETSVPSARD 1200 KELLPPSGLP 1210 PKIGSISRQP 1220 SVSEKKVPEP 1230 SPVTRRKAYE 1240 KADKAKTKEQ 1250 KHSDSGASET 1260 SLSPPSSPPS 1270 RPRNELNVFN 1280 RLTVSQGSAP 1290 VQQDKSDESD 1300 PSLSEVHRGI 1310 INPFPACRGI 1320 RASFLQCVHV 1330 AEGHTKAVLC 1340 VDSTDDLLFT 1350 GSKDRTCKVW 1360 NLVTGQEIMS 1370 LGVHPNNVVS 1380 VKYCNYTSLV 1390 FTVSTSYIKV 1400 WDIRESAKCI 1410 RTLTSSGQVT 1420 LGEACSASTS 1430 RTVAIPSGES 1440 QINQIALNPT 1450 GTFLYAASGN 1460 AVRMWDLKRF 1470 QSTGKLTGHL 1480 GPVMCLTVDQ 1490 ISNGQDLIIT 1500 GSKDHYIKMF 1510 DVTEGALGTV 1520 SPTHNFEPPH 1530 YDGIEALAIQ 1540 GDNLFSGSRD 1550 NGIKKWDLAQ 1560 KGLLQQVPNA 1570 HKDWVCALGL 1580 VPGHPILLSG 1590 CRGGILKLWN 1600 VDTFVPVGEM 1610 RGHDSPINAI 1620 SVNSTHVFTA 1630 ADDRTVRIWK 1640 AHNLQDGQIS 1650 DTGDPGEDST SN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0030426	growth cone
Cellular Component	GO:0005874	microtubule
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0003777	microtubule motor activity
Biological Process	GO:0007018	microtubule-based movement

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.