Overview
| Uniprot ID | A0A8I6AMG3 |
|---|
| Protein Name | Very-long-chain enoyl-CoA reductase |
|---|
| Gene Name | Tecr |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 2 |
******MKHYEVEIR |
Function
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA
Protein Sequence
10
MKHYEVEIRD
20
AKTREKLCFL
30
DKVEPQATIS
40
EIKTLFTKTH
50
PQWYPARQSL
60
RLDPKGKSLK
70
DEDVLQKLPV
80
GTTATLYFRD
90
LGAQISWVTV
100
FLTEYAGPLF
110
IYLLFYFRVP
120
FIYGRKYDFT
130
SSRHTVVHLA
140
CMCHSFHYIK
150
RLLETLFVHR
160
FSHGTMPLRN
170
IFKNCTYYWG
180
FAAWMAYYIN
190
HPLYTPPTYG
200
VQQVKLALAI
210
FVICQLGNFS
220
IHMALRDLRP
230
AGSKTRKIPY
240
PTKNPFTWLF
250
LLVSCPNYTY
260
EVGSWIGFAI
270
MTQCVPGHEV
280
GKAVAFALQQ
290
PDEVVRTVVT
LL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0102758 |
very-long-chain enoyl-CoA reductase activity |
| Biological Process |
GO:0006633 |
fatty acid biosynthetic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.