Overview
| Uniprot ID | A0A8I6AMG4 |
| Protein Name | Nuclear receptor corepressor 1 |
| Gene Name | Ncor1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1295 |
VREEAASKGHVIYEG |
| 1493 |
SAIKHNVKSLITGPS |
| 1501 |
SLITGPSKLPRGMLE |
| 695 |
DNLLQQHKQKVSRAV |
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver
Protein Sequence
10
MSSSGYPPNQ
20
GAFSTEQSRY
30
PSQSVQYTFP
40
STRHQQEFAV
50
PDYRSSHIEV
60
SQASQLLQQQ
70
QQQQQLRRRP
80
SLLSEFHPGS
90
DRAGDRTQGL
100
VLPRPQERRT
110
GYEQFHSGPS
120
PVDHDSLESK
130
RPRLEPVSDA
140
HFQRVSAAVL
150
PLVHTLPEGL
160
RASADAKKDS
170
AFGGKHEAPS
180
SPLAGQPCGD
190
DQNASPSKLS
200
KEELIQSMDR
210
VDREIAKVEQ
220
QILKLKKKQQ
230
QLEEEAAKPP
240
EPEKPVSPPP
250
VEQKHRSIVQ
260
IIYDENRKKA
270
EEAHKIFEGL
280
GPKVELPLYN
290
QPSDTKVYHE
300
NIKTNQVMRK
310
KLILFFKRRN
320
HARKQREQKI
330
CQRYDQLMEA
340
WEKKVDRIEN
350
NPRRKAKESK
360
TREYYEKQFP
370
EIRKQREQQE
380
RFQRVGQRGA
390
GLSATIARSE
400
HEISEIIDGL
410
SEQENNEKQM
420
RQLSVIPPMM
430
FDAEQRRVKF
440
INMNGLMEDP
450
MKVYKDRQFM
460
NVWTDHEKEI
470
FKDKFIQHPK
480
NFGLIASYLE
490
RKSVPDCVLY
500
YYLTKKNENY
510
KALVRRNYGK
520
RRGRNQQIAR
530
PSQEEKVEEK
540
EEDKAEKMEK
550
KEEEKKDDEE
560
KDEKEESKET
570
TKEKDRTEAT
580
AEETEEREQV
590
TPRGRKTANS
600
QGRRKGRITR
610
SMTSEAAAAS
620
AAAAATEEPP
630
PPLPPPPEPV
640
STEPVETSRW
650
TEEEMEVAKK
660
GLVEHGRNWA
670
AIAKMVGTKS
680
EAQCKNFYFN
690
YKRRHNLDNL
700
LQQHKQKVSR
710
AVVASRKPRE
720
ERDVSQCESV
730
ASTVSAQEDE
740
DIEASNEEEN
750
PEDSEGAENS
760
SDTESAPSPS
770
PVEAAKSSED
780
SSENAASRGN
790
TEPVAELEAT
800
TDPAPCASPS
810
SAVPTTKPAE
820
SESVEAQVTD
830
SASVETAEPM
840
DVDHEECGAQ
850
GSSVLDPPAP
860
TKADSVDPEI
870
QVPENTASKG
880
EGDAKDRDLE
890
SASEKTEARD
900
EDLVVAEQMQ
910
RPEPQSDNDS
920
SATCSADEDV
930
DGEPERQRVF
940
PMDAKPSLLN
950
PPGSILISSP
960
IKPNPLDLPQ
970
LQHRAAVIPP
980
MVSCTPCNIP
990
IGTPVSGYAL
1000
YQRHIKAMHE
1010
SALLEEQRQR
1020
QEQIDLECRS
1030
STSPCGTSKS
1040
PNREWEGKSV
1050
AYMPYAEVKR
1060
ALEQEAQMHS
1070
TAARSASPCR
1080
LSPREVSKAA
1090
SQPDMSAARY
1100
SVPPVLQPAP
1110
HQVITNLPEG
1120
VRLPTTRPTR
1130
PPPPLIPSSK
1140
TTVASEKPSF
1150
IMGGSISQGT
1160
PGTYLTSHSQ
1170
AYTPEAAKPS
1180
VGSISLGLPR
1190
QQESTKSAPL
1200
TYIKQEEFSP
1210
RSQNSQPEGL
1220
LVRAQHEGVV
1230
RGTAGAVQEG
1240
SITRGTPASK
1250
ISVESISSLR
1260
GSITQGTPAL
1270
PQAGIPTEAL
1280
VKGPVSRMPI
1290
EESSPEKVRE
1300
EAASKGHVIY
1310
EGKSGHILSY
1320
DNIKNAREGT
1330
RSPRTAHEMS
1340
LKRSYESVEG
1350
NVKQGMSMRE
1360
SPVSAAPLEG
1370
LICRALPRGS
1380
PHSDLKERTV
1390
LSGSIMQGTP
1400
RATAESFEDG
1410
LKYPKQIKRE
1420
SPPSRAFEGA
1430
ITKGKPYDGI
1440
TTIKEMGRSI
1450
HEIPRQDILT
1460
QESRKTPEVV
1470
QSTRPIIEGS
1480
ISQGTPIKFD
1490
NNSGQSAIKH
1500
NVKSLITGPS
1510
KLPRGMLEIV
1520
PENIKVVERG
1530
KYEDVKAGEP
1540
VRPRHTSVVS
1550
SGPSVLRSTL
1560
HEAPKAQLSP
1570
GIYDDSSARR
1580
TPVSYQNTIS
1590
RGSPMMNRTS
1600
DGSSSKTTSH
1610
ERKSALTPTQ
1620
RESVPAKSPV
1630
PAVDSVVSHS
1640
PFDPHHRSTT
1650
AGEVYRSHLP
1660
THLDPAMPFH
1670
RALDPAAAAY
1680
LFQRQLSPTP
1690
GYPSQYQLYA
1700
MENTRQTILN
1710
DYITSQQMQV
1720
NLRPDVARGL
1730
SPREQPLGLP
1740
YPATRGIIDL
1750
TNMPPTILVP
1760
HAGGTSTPPM
1770
DRITYIPGTQ
1780
ITFPPRPYNA
1790
ASLSPGHPTH
1800
LAAAASAERE
1810
REREREKERE
1820
RERERERERE
1830
RERERERERE
1840
RERERITAAP
1850
TDLYLRPGSE
1860
QPGRPGSHGY
1870
VRSPSPSVRT
1880
QETMLQQRPS
1890
VFQGTNGTSV
1900
ITPLDPTAQL
1910
RIMPLPSGGP
1920
SISQGLPASR
1930
YNTAADALAA
1940
LVDAAASAPQ
1950
MDVSKTKESK
1960
HEAARLEDNV
1970
RSRSAAVSEQ
1980
QQLEQKNLEV
1990
EKRSVQCVCT
2000
SSALPSGKPQ
2010
PHASVVYSEA
2020
GKDKGPPPKS
2030
RYEEELRTRG
2040
KTTITAANFI
2050
DVIITRQIAS
2060
DKDARERGSQ
2070
SSDSSSSLSS
2080
HRYEAPSDAI
2090
EVISPASSPA
2100
PPQEKPQAYQ
2110
PEMVKANQAE
2120
NESPQQYEGP
2130
LHHYRSQQGS
2140
PSPQQQPPLP
2150
PSSQAEGMGQ
2160
VPRTHRLITL
2170
ADHICQIITQ
2180
DFARNQVPSQ
2190
PSTSTFQTSP
2200
SALSSTPVRT
2210
KPSSRYSPES
2220
QSQTVLHPRP
2230
GPRVSPENLV
2240
DKSRGSRPGK
2250
SPERSHIPSE
2260
PYEPISPPQG
2270
PAVHEKQDSM
2280
LLLSQRGMDP
2290
AEQRSDSRSP
2300
GSISYLPSFF
2310
TKLESTSPMV
2320
KSKKQEIFRK
2330
LNSSGGGDSD
2340
MAAAQPGTEI
2350
FNLPAVTTSG
2360
AVSSRSHSFA
2370
DPASNLGLED
2380
IIRKALMGSF
2390
DDKVEDHGVV
2400
MPHPVGVVPG
2410
SASTSVVTSS
2420
ETRRDEGDPS
2430
PHSGVCKPKL
2440
INKSNSRKSK
2450
SPIPGQNYLG
2460
TERPSSVSSV
2470
HSEGDYHRQT
2480
PGWAWEDRPS
2490
STGSTQFPYN
2500
PLTIRMLSST
2510
PPTPIACAPS
2520
AITQAAPHQQ
2530
SRIWEREPAP
2540
LLSAQYETLS
DSDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0017053 |
transcription repressor complex |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0016922 |
nuclear receptor binding |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0061436 |
establishment of skin barrier |
| Biological Process |
GO:0030900 |
forebrain development |
| Biological Process |
GO:0001701 |
in utero embryonic development |
| Biological Process |
GO:1902532 |
negative regulation of intracellular signal transduction |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:0048511 |
rhythmic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.