Search Results

Overview

Uniprot IDA0A8I6AMG4
Protein NameNuclear receptor corepressor 1
Gene NameNcor1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1295 VREEAASKGHVIYEG
1493 SAIKHNVKSLITGPS
1501 SLITGPSKLPRGMLE
695 DNLLQQHKQKVSRAV

Function

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver

Protein Sequence

10 MSSSGYPPNQ 20 GAFSTEQSRY 30 PSQSVQYTFP 40 STRHQQEFAV 50 PDYRSSHIEV 60 SQASQLLQQQ 70 QQQQQLRRRP 80 SLLSEFHPGS 90 DRAGDRTQGL 100 VLPRPQERRT 110 GYEQFHSGPS 120 PVDHDSLESK 130 RPRLEPVSDA 140 HFQRVSAAVL 150 PLVHTLPEGL 160 RASADAKKDS 170 AFGGKHEAPS 180 SPLAGQPCGD 190 DQNASPSKLS 200 KEELIQSMDR 210 VDREIAKVEQ 220 QILKLKKKQQ 230 QLEEEAAKPP 240 EPEKPVSPPP 250 VEQKHRSIVQ 260 IIYDENRKKA 270 EEAHKIFEGL 280 GPKVELPLYN 290 QPSDTKVYHE 300 NIKTNQVMRK 310 KLILFFKRRN 320 HARKQREQKI 330 CQRYDQLMEA 340 WEKKVDRIEN 350 NPRRKAKESK 360 TREYYEKQFP 370 EIRKQREQQE 380 RFQRVGQRGA 390 GLSATIARSE 400 HEISEIIDGL 410 SEQENNEKQM 420 RQLSVIPPMM 430 FDAEQRRVKF 440 INMNGLMEDP 450 MKVYKDRQFM 460 NVWTDHEKEI 470 FKDKFIQHPK 480 NFGLIASYLE 490 RKSVPDCVLY 500 YYLTKKNENY 510 KALVRRNYGK 520 RRGRNQQIAR 530 PSQEEKVEEK 540 EEDKAEKMEK 550 KEEEKKDDEE 560 KDEKEESKET 570 TKEKDRTEAT 580 AEETEEREQV 590 TPRGRKTANS 600 QGRRKGRITR 610 SMTSEAAAAS 620 AAAAATEEPP 630 PPLPPPPEPV 640 STEPVETSRW 650 TEEEMEVAKK 660 GLVEHGRNWA 670 AIAKMVGTKS 680 EAQCKNFYFN 690 YKRRHNLDNL 700 LQQHKQKVSR 710 AVVASRKPRE 720 ERDVSQCESV 730 ASTVSAQEDE 740 DIEASNEEEN 750 PEDSEGAENS 760 SDTESAPSPS 770 PVEAAKSSED 780 SSENAASRGN 790 TEPVAELEAT 800 TDPAPCASPS 810 SAVPTTKPAE 820 SESVEAQVTD 830 SASVETAEPM 840 DVDHEECGAQ 850 GSSVLDPPAP 860 TKADSVDPEI 870 QVPENTASKG 880 EGDAKDRDLE 890 SASEKTEARD 900 EDLVVAEQMQ 910 RPEPQSDNDS 920 SATCSADEDV 930 DGEPERQRVF 940 PMDAKPSLLN 950 PPGSILISSP 960 IKPNPLDLPQ 970 LQHRAAVIPP 980 MVSCTPCNIP 990 IGTPVSGYAL 1000 YQRHIKAMHE 1010 SALLEEQRQR 1020 QEQIDLECRS 1030 STSPCGTSKS 1040 PNREWEGKSV 1050 AYMPYAEVKR 1060 ALEQEAQMHS 1070 TAARSASPCR 1080 LSPREVSKAA 1090 SQPDMSAARY 1100 SVPPVLQPAP 1110 HQVITNLPEG 1120 VRLPTTRPTR 1130 PPPPLIPSSK 1140 TTVASEKPSF 1150 IMGGSISQGT 1160 PGTYLTSHSQ 1170 AYTPEAAKPS 1180 VGSISLGLPR 1190 QQESTKSAPL 1200 TYIKQEEFSP 1210 RSQNSQPEGL 1220 LVRAQHEGVV 1230 RGTAGAVQEG 1240 SITRGTPASK 1250 ISVESISSLR 1260 GSITQGTPAL 1270 PQAGIPTEAL 1280 VKGPVSRMPI 1290 EESSPEKVRE 1300 EAASKGHVIY 1310 EGKSGHILSY 1320 DNIKNAREGT 1330 RSPRTAHEMS 1340 LKRSYESVEG 1350 NVKQGMSMRE 1360 SPVSAAPLEG 1370 LICRALPRGS 1380 PHSDLKERTV 1390 LSGSIMQGTP 1400 RATAESFEDG 1410 LKYPKQIKRE 1420 SPPSRAFEGA 1430 ITKGKPYDGI 1440 TTIKEMGRSI 1450 HEIPRQDILT 1460 QESRKTPEVV 1470 QSTRPIIEGS 1480 ISQGTPIKFD 1490 NNSGQSAIKH 1500 NVKSLITGPS 1510 KLPRGMLEIV 1520 PENIKVVERG 1530 KYEDVKAGEP 1540 VRPRHTSVVS 1550 SGPSVLRSTL 1560 HEAPKAQLSP 1570 GIYDDSSARR 1580 TPVSYQNTIS 1590 RGSPMMNRTS 1600 DGSSSKTTSH 1610 ERKSALTPTQ 1620 RESVPAKSPV 1630 PAVDSVVSHS 1640 PFDPHHRSTT 1650 AGEVYRSHLP 1660 THLDPAMPFH 1670 RALDPAAAAY 1680 LFQRQLSPTP 1690 GYPSQYQLYA 1700 MENTRQTILN 1710 DYITSQQMQV 1720 NLRPDVARGL 1730 SPREQPLGLP 1740 YPATRGIIDL 1750 TNMPPTILVP 1760 HAGGTSTPPM 1770 DRITYIPGTQ 1780 ITFPPRPYNA 1790 ASLSPGHPTH 1800 LAAAASAERE 1810 REREREKERE 1820 RERERERERE 1830 RERERERERE 1840 RERERITAAP 1850 TDLYLRPGSE 1860 QPGRPGSHGY 1870 VRSPSPSVRT 1880 QETMLQQRPS 1890 VFQGTNGTSV 1900 ITPLDPTAQL 1910 RIMPLPSGGP 1920 SISQGLPASR 1930 YNTAADALAA 1940 LVDAAASAPQ 1950 MDVSKTKESK 1960 HEAARLEDNV 1970 RSRSAAVSEQ 1980 QQLEQKNLEV 1990 EKRSVQCVCT 2000 SSALPSGKPQ 2010 PHASVVYSEA 2020 GKDKGPPPKS 2030 RYEEELRTRG 2040 KTTITAANFI 2050 DVIITRQIAS 2060 DKDARERGSQ 2070 SSDSSSSLSS 2080 HRYEAPSDAI 2090 EVISPASSPA 2100 PPQEKPQAYQ 2110 PEMVKANQAE 2120 NESPQQYEGP 2130 LHHYRSQQGS 2140 PSPQQQPPLP 2150 PSSQAEGMGQ 2160 VPRTHRLITL 2170 ADHICQIITQ 2180 DFARNQVPSQ 2190 PSTSTFQTSP 2200 SALSSTPVRT 2210 KPSSRYSPES 2220 QSQTVLHPRP 2230 GPRVSPENLV 2240 DKSRGSRPGK 2250 SPERSHIPSE 2260 PYEPISPPQG 2270 PAVHEKQDSM 2280 LLLSQRGMDP 2290 AEQRSDSRSP 2300 GSISYLPSFF 2310 TKLESTSPMV 2320 KSKKQEIFRK 2330 LNSSGGGDSD 2340 MAAAQPGTEI 2350 FNLPAVTTSG 2360 AVSSRSHSFA 2370 DPASNLGLED 2380 IIRKALMGSF 2390 DDKVEDHGVV 2400 MPHPVGVVPG 2410 SASTSVVTSS 2420 ETRRDEGDPS 2430 PHSGVCKPKL 2440 INKSNSRKSK 2450 SPIPGQNYLG 2460 TERPSSVSSV 2470 HSEGDYHRQT 2480 PGWAWEDRPS 2490 STGSTQFPYN 2500 PLTIRMLSST 2510 PPTPIACAPS 2520 AITQAAPHQQ 2530 SRIWEREPAP 2540 LLSAQYETLS DSDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0030900 forebrain development
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:1902532 negative regulation of intracellular signal transduction
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0050821 protein stabilization
Biological Process GO:0048511 rhythmic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.