Search Results
Overview
| Uniprot ID | A0A8I6AN14 |
|---|---|
| Protein Name | Mitochondrial peptide methionine sulfoxide reductase |
| Gene Name | Msra |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | EYQKVLSKHGFGPIT |
| 62 | YTRNPTYKEVCSEKT |
Function
Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency
Protein Sequence
10
MSKAKHHVSG
20
NRTVEPFPEG
30
TQMAVFGMGC
40
FWGAERKFWL
50
LKGVYSTQVG
60
FAGGYTRNPT
70
YKEVCSEKTG
80
HAEVVRVVYR
90
PEHVSFEELL
100
KVFWENHDPT
110
QGMRQGNDCG
120
TQYRSAVYPT
130
SAVQMEAALK
140
SKEEYQKVLS
150
KHGFGPITTD
160
IREGQVFYYA
170
EDYHQQYLSK
180
NPDGYCGLGG
190
TGVSCPTAIK
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.