Search Results
Overview
| Uniprot ID | A0A8I6ANV0 |
|---|---|
| Protein Name | Phosphodiesterase |
| Gene Name | Pde1b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 433 | PLTDDDSKSKSQPSF |
Function
Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate
Protein Sequence
10
MANPVPVQRS
20
HLQGPILRLR
30
YMVKQLENGE
40
VNIEELKKNL
50
EYTASLLEAV
60
YIDETRQILD
70
TEDELRELRS
80
DAVPSEVRDW
90
LASTFTQQTR
100
AKGRRAEEKP
110
KFRSIVHAVQ
120
AGIFVERMFR
130
RTYTAVGPTY
140
STAVHNCLKN
150
LDVWCFDVFS
160
LNRAADDHAL
170
RTIVFELLTR
180
HSLISRFKIP
190
TVFLMSFLEA
200
LETGYGKYKN
210
PYHNQIHAAD
220
VTQTVHCFLL
230
RTGMVHCLSE
240
IEVLAIIFAA
250
AIHDYEHTGT
260
TNSFHIQTKS
270
ECAILYNDRS
280
VLENHHISSV
290
FRMMQDDEMN
300
IFINLTKDEF
310
VELRALVIEM
320
VLATDMSCHF
330
QQVKTMKTAL
340
QQLERIDKSK
350
ALSLLLHAAD
360
ISHPTKQWSV
370
HSRWTKALME
380
EFFRQGDKEA
390
ELGLPFSPLC
400
DRTSTLVAQS
410
QIGFIDFIVE
420
PTFSVLTDVA
430
EKSVQPLTDD
440
DSKSKSQPSF
450
QWRQPSLDVD
460
VGDPNPDVVS
470
FRSTWTKYIQ
480
ENKQKWKERA
490
ASGITNQMSI
500
DELSPCEEEA
510
PSSPAEDEHN
QNGNLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.