Search Results

Overview

Uniprot ID	A0A8I6ANW0
Protein Name	Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Gene Name	Acsf2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
182	IVFPKQFKTQQYYNI
199	QVCPELEKAQPGALK
340	SPSFNGKKALEAISR
489	CRIVGRSKDMIIRGG
555	IKAFCKGKISHFKIP

Function

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation

Protein Sequence

10 MAVYLGMLRL 20 GRLCVASLGA 30 RGPRTPLSRP 40 WPNSKLQGVR 50 AFSSGMVDCT 60 NPLPIGGLSY 70 IQGHTDSHLV 80 NKTVGECLDA 90 TAQRFPNREA 100 LVIIHENIRL 110 NFAQLKEEVD 120 RAASGLLSIG 130 LRKGDRLGMW 140 GPNSYAWVLI 150 QLATAQAGII 160 LVSVNPAYQA 170 SELEYVLRKV 180 GCKGIVFPKQ 190 FKTQQYYNIL 200 KQVCPELEKA 210 QPGALKSERL 220 PDLTTVISVD 230 APLPGTLLLD 240 EVVAAGGKEQ 250 NLAQLRYHQG 260 FLSCYDPINI 270 QFTSGTTGNP 280 KGATLSHHNI 290 VNNSNLIGQR 300 LKMPAKTAEE 310 LRMVLPCPLY 320 HCLGSVGGTM 330 VSVVHGATLL 340 LSSPSFNGKK 350 ALEAISREKG 360 TLLYGTPTMF 370 VDILNQPDFS 380 SYDFTTIRGG 390 WVTTVVYGTT 400 ENSPVTFMNF 410 PEDTLEQKAG 420 SVGRIMPHTE 430 AQIVNMETGE 440 LTKLNMPGEL 450 CIRGYCVMQG 460 YWGEPQKTFE 470 TVGQDRWYRT 480 GDIASMDEQG 490 FCRIVGRSKD 500 MIIRGGENIY 510 PAELEDFFHK 520 HPQVQEAQVV 530 GVKDDRMGEE 540 ICACIRLKSG 550 ETTTEEEIKA 560 FCKGKISHFK 570 IPRYIVFVEG 580 YPLTVSGKIQ 590 KFKLREQMEQ HLKL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0031956	medium-chain fatty acid-CoA ligase activity
Biological Process	GO:0006629	lipid metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.