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Overview

Uniprot IDA0A8I6APA7
Protein NameNeurofilament heavy polypeptide
Gene NameNefh
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1011 KDSQPSEKAPEDKAA
1019 APEDKAAKGDK****
114 RFAGYIDKVRQLEAH
219 ARVELQKKAQALQEE
264 AEARDALKCDVTSAL
305 DRLSEAAKVNTDAMR
336 TTELEALKSTKESLE
375 DNELRNTKWEMAAQL
525 AKSPAEAKSPAEAKS
549 VKSPAVAKSPAEVKS
567 VKSPAEAKSPAEAKS
597 AKSPASVKSPGEAKS
687 AKSPAEAKSPAEAKS
693 AKSPAEAKSPAEAKS
699 AKSPAEAKSPAEAKS
717 VKSPEKAKSPVKEGA
761 EKAKSPMKEEAKSPE
897 EAKKEEAKEKKAAAP
930 KAEDAKAKEPSKPSE
98 AVAARSEKEQLQALN
994 PSKPKTEKAEKSSST

Function

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks

Protein Sequence

10 MMSFGGADAL 20 LGAPFAPLHG 30 GGSLHYALSR 40 KAGAGGTRSA 50 AGSSSGFHSW 60 ARTSVSSVSA 70 SPSRFRGAGA 80 ASSTDSLDTL 90 SNGPEGCVVA 100 AVAARSEKEQ 110 LQALNDRFAG 120 YIDKVRQLEA 130 HNRSLEGEAA 140 ALRQQQAGRA 150 AMGELYEREV 160 REMRGAVLRL 170 GAARGQLRLE 180 QEHLLEDIAH 190 VRQRLDEEAR 200 QREEAEAAAR 210 ALARFAQEAE 220 AARVELQKKA 230 QALQEECGYL 240 RRHHQEEVGE 250 LLGQIQGCGA 260 AQAQAQAEAR 270 DALKCDVTSA 280 LREIRAQLEG 290 HTVQSTLQSE 300 EWFRVRLDRL 310 SEAAKVNTDA 320 MRSAQEEITE 330 YRRQLQARTT 340 ELEALKSTKE 350 SLERQRSELE 360 DRHQVDMASY 370 QDAIQQLDNE 380 LRNTKWEMAA 390 QLREYQDLLN 400 VKMALDIEIA 410 AYRKLLEGEE 420 CRIGFGPSPF 430 SLTEGLPKIP 440 SMSTHIKVKS 450 EEKIKVVEKS 460 EKETVIVEEQ 470 TEEIQVTEEV 480 TEEEDKEAQG 490 EEEEEAEEGG 500 EEAATTSPPA 510 EEAASPEKET 520 KSPVKEEAKS 530 PAEAKSPAEA 540 KSPAEAKSPA 550 EVKSPAVAKS 560 PAEVKSPAEV 570 KSPAEAKSPA 580 EAKSPAEVKS 590 PVEAKSPAEA 600 KSPASVKSPG 610 EAKSPAEAKS 620 PAEVKSPVTV 630 KSPAEAKSPV 640 EVKSPASVKS 650 PSEAKSPAGA 660 KSPAEAKSPV 670 VAKSPAEAKS 680 PAEAKPPAEA 690 KSPAEAKSPA 700 EAKSPAEAKS 710 PAEAKSPVEV 720 KSPEKAKSPV 730 KEGAKSLAEA 740 KSPEKAKSPV 750 KEEIKPPAEV 760 KSPEKAKSPM 770 KEEAKSPEKA 780 KTLDVKSPEA 790 KTPAKEEAKR 800 PADIRSPEQV 810 KSPAKEEAKS 820 PEKEETRTEK 830 VAPKKEEVKS 840 PVEEVKAKEP 850 PKKVEEEKTP 860 ATPKTEVKES 870 KKDEAPKEAQ 880 KPKAEEKEPL 890 TEKPKDSPGE 900 AKKEEAKEKK 910 AAAPEEETPA 920 KLGVKEEAKP 930 KEKAEDAKAK 940 EPSKPSEKEK 950 PKKEEVPAAP 960 EKKDTKEEKT 970 TESKKPEEKP 980 KMEAKAKEED 990 KGLPQEPSKP 1000 KTEKAEKSSS 1010 TDQKDSQPSE 1020 KAPEDKAAKG DK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005882 intermediate filament

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.