Search Results

Overview

Uniprot ID	A0A8I6AQ31
Protein Name	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Gene Name	Mccc1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
209	MRIIRSEKEFQEQLE
224	SARREAKKSFNDDAM
683	PKDGRIKKVFFSEGA

Function

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Protein Sequence

10 GFTSYKMGLF 20 NRLSGQMEWP 30 WKHRTVKYGT 40 TPGGSITKVL 50 IANRGEIACR 60 VIRTARKMGV 70 QSVAVYSEAD 80 RNSMHVDMAD 90 EAYSIGPAPS 100 QQSYLAMEKI 110 IQVAKSSAAQ 120 AIHPGYGFLS 130 ENMEFAELCK 140 QEGIIFIGPP 150 STAIRDMGIK 160 STSKSIMAAA 170 GVPVVEGYHG 180 NDQSDECLKE 190 HAGKIGYPVM 200 IKAIRGGGGK 210 GMRIIRSEKE 220 FQEQLESARR 230 EAKKSFNDDA 240 MLIEKFVDTP 250 RHVEVQVFGD 260 HHGNAVYLFE 270 RDCSVQRRHQ 280 KIIEEAPAPG 290 IDPEVRRRLG 300 EAAVRAAKAV 310 NYVGAGTVEF 320 IMDSKHNFYF 330 MEMNTRLQVE 340 HPVTEMITGT 350 DLVEWQLRIA 360 AGEKIPLSQE 370 EIPLQGHAFE 380 ARIYAEDPDN 390 NFMPGAGPLV 400 HLSTPPPDMS 410 TRIETGVRQG 420 DEVSVHYDPM 430 IAKLVVWASD 440 RQSALSKLRY 450 SLHQYNIVGL 460 RTNVDFLLRL 470 SGHSEFEAGN 480 VHTDFIPQHH 490 KDLLPTHSTI 500 AKESVCQAAL 510 GLILKEKEMT 520 SAFKLHTQDQ 530 FSPFSFSSGR 540 RLNISYTRNM 550 TLRSGKNDII 560 IAVTYNRDGS 570 YDMQIENKLF 580 RVLGDLSNED 590 GYTYLKSSVN 600 GVASKSKFIL 610 LDNTIYLFSM 620 EGSIEVGIPV 630 PKYLSPVSAE 640 GTQGGTIAPM 650 TGTIEKVFVK 660 AGDRVKAGDA 670 LMVMIAMKME 680 HTIKAPKDGR 690 IKKVFFSEGA 700 QANRHAPLVE FEEEEV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004485	methylcrotonoyl-CoA carboxylase activity
Biological Process	GO:0019752	carboxylic acid metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.