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Overview

Uniprot IDA0A8I6AR12
Protein NameT-complex protein 1 subunit eta
Gene NameCct7
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
135 ATQLAVNKIKEIAVT
368 FTGCPKAKTCTIILR
55 LIVDGRGKATISNDG

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia

Protein Sequence

10 MMPTPVILLK 20 EGTDSSQGIP 30 QLVSNISACQ 40 VIAEAVRTTL 50 GPRGMDKLIV 60 DGRGKATISN 70 DGATILKLLD 80 VVHPAAKTLV 90 DIAKSQDAEV 100 GDGTTSVTLL 110 AAEFLKQVKP 120 YVEEGLHPQI 130 IIRAFRTATQ 140 LAVNKIKEIA 150 VTVKKQDKVE 160 QRKMLEKCAM 170 TALSSKLISQ 180 QKVFFAKMVV 190 DAVMMLDELL 200 QLKMIGIKKV 210 QGGALEESRL 220 VAGVAFKKTF 230 SYAGFEMQPK 240 KYKNPKIALL 250 NVELELKAEK 260 DNAEIRVHTV 270 EDYQAIVDAE 280 WNILYDKLEK 290 IHQSGAKVIL 300 SKLPIGDVAT 310 QYFADRDMFC 320 AGRVPEEDLK 330 RTMMACGGSI 340 QTSVNALIPD 350 VLGRCQVFEE 360 TQIGGERYNF 370 FTGCPKAKTC 380 TIILRGGAEQ 390 FMEETERSLH 400 DAIMIVRRAI 410 KNDSVVAGGG 420 AIEMELSKYL 430 RDYSRTIPGK 440 QQLLIGAYAK 450 ALEIIPRQLC 460 DNAGFDATNI 470 LNKLRARHAQ 480 GGMWYGVDIN 490 NEDIADNFQA 500 FVWEPAMVRI 510 NALTAASEAA 520 CLIVSVDETI 530 KNPRSTVDAP 540 APAAGRGRGQ GRFH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044297 cell body
Cellular Component GO:0005832 chaperonin-containing T-complex
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0044183 protein folding chaperone
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0007339 binding of sperm to zona pellucida
Biological Process GO:0032212 positive regulation of telomere maintenance via telomerase
Biological Process GO:0006457 protein folding
Biological Process GO:0050821 protein stabilization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.