Overview
| Uniprot ID | A0A8I6AS56 |
|---|
| Protein Name | sn-1-specific diacylglycerol lipase ABHD11 |
|---|
| Gene Name | Abhd11 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 227 |
IPHSRARKLADEQLS |
| 238 |
EQLSSVVKEASVRQF |
Function
Catalyzes the hydrolysis of diacylglycerol in vitro and may function as a key regulator in lipid metabolism, namely by regulating the intracellular levels of diacylglycerol. 1,2-diacyl-sn-glycerols are the preferred substrate over 1,3-diacyl-sn-glycerols. The enzyme hydrolyzes stearate in preference to palmitate from the sn-1 position of 1,2-diacyl-sn-glycerols. Maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (OGDHc) through its interaction with the OGDHc by preventing the formation of lipoyl adducts. In addition, is also required for the expansion and differentiation of embryonic stem cells (ESCs)
Protein Sequence
10
MPRTWQGLTG
20
VRRFLSRSVA
30
AAVVAKETLI
40
RGQSRTPGRW
50
PFTGPLRTRP
60
SRPRPSFSHG
70
PFLLHSPHPY
80
SMVAPPSRPL
90
PLSYNLLDGD
100
ATLPAIVLLH
110
GLFGSKSNFN
120
SLAKALVQRT
130
GRRVLTVDAR
140
NHGDSPHSPD
150
ASYEAMSQDL
160
QGLLPQLGLV
170
PSVLVGHSMG
180
GKTAMLLALQ
190
RPDVVERLVV
200
VDISPAGTTP
210
GSYLGNFIAA
220
MKAVDIPENI
230
PHSRARKLAD
240
EQLSSVVKEA
250
SVRQFLLTNL
260
VEVNGRFSWR
270
VNLDALAQQL
280
DKILTFPQQL
290
ESYPGSTLFL
300
LGGNSPYVPP
310
SHHSAIRRLF
320
PQTQIQTVPN
330
AGHWVHSDKP
340
QDFMDAVISF
LA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045252 |
oxoglutarate dehydrogenase complex |
| Molecular Function |
GO:0052689 |
carboxylic ester hydrolase activity |
| Molecular Function |
GO:0016298 |
lipase activity |
| Biological Process |
GO:0006629 |
lipid metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.