Overview
| Uniprot ID | A0A8I6ASY3 |
|---|
| Protein Name | Anamorsin |
|---|
| Gene Name | Ciapin1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 208 |
HKKSSSVKPVVDPAT |
| 268 |
GKKRKACKNCTCGLA |
Function
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells
Protein Sequence
10
MWSRDLAVTS
20
HLQVAFRSSS
30
SAGMAEFGIS
40
PGQLVAVFCD
50
KSSSEEALKK
60
LVGRVQGLTG
70
SEGQVFVENI
80
TQLLQSAHKE
90
SSFDVILSGI
100
VPGSTSLHSP
110
EALADMARIL
120
RPGGCLFLKE
130
PVETTGVNND
140
KIKTASKLCS
150
ALTLSGLVEI
160
KELQREALSP
170
EEAQSMQEHL
180
GYHSDSLLSV
190
HVTGKKPNFE
200
VGSSSQLKLL
210
HKKSSSVKPV
220
VDPATAKLWT
230
LSANDMEDDS
240
MDLIDSDELL
250
DPEDLKKPDP
260
ASLKAPSCGE
270
GKKRKACKNC
280
TCGLAEELEK
290
EQSKAQSSQP
300
KSACGNCYLG
310
DAFRCANCPY
320
LGMPAFKPGE
330
QVLLSSSNLQ
DA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0051537 |
2 iron, 2 sulfur cluster binding |
| Molecular Function |
GO:0051539 |
4 iron, 4 sulfur cluster binding |
| Molecular Function |
GO:0009055 |
electron transfer activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0030097 |
hemopoiesis |
| Biological Process |
GO:0016226 |
iron-sulfur cluster assembly |
| Biological Process |
GO:0043066 |
negative regulation of apoptotic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.