Search Results
Overview
| Uniprot ID | A0A8I6AT28 |
|---|---|
| Protein Name | Neuroplastin |
| Gene Name | Nptn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | ATISVLQKPRIVTSE |
| 228 | APDITGHKRSENKNE |
| 233 | GHKRSENKNEGQDAM |
Function
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane
Protein Sequence
10
SSSKSLYELL
20
LLSLYTGFVK
30
SPMSETKLTG
40
DAFELYCDVV
50
GSPTPEIQWW
60
YAEVNRAESF
70
RQLWDGARKR
80
RVTVNTAYGS
90
NGVSVLRITR
100
LTLEDSGTYE
110
CRASNDPKRN
120
DLRQNPSITW
130
IRAQATISVL
140
QKPRIVTSEE
150
VIIRDSLLPV
160
TLQCNLTSSS
170
HTLMYSYWTK
180
NGVELTATRK
190
NASNMEYRIN
200
KPRAEDSGEY
210
HCVYHFVSAP
220
KANATIEVKA
230
APDITGHKRS
240
ENKNEGQDAM
250
MYCKSVGYPH
260
PEWMWRKKEN
270
GVFEEISNSS
280
GRFFIINKEN
290
YTELNIVNLQ
300
ITEDPGEYEC
310
NATNSIGSAS
320
VSTVLRVRSH
330
LAPLWPFLGI
340
LAEIIILVVI
350
IVVYEKRKRP
360
DEVPDGKSIP
TK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0050804 | modulation of chemical synaptic transmission |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0060255 | regulation of macromolecule metabolic process |
| Biological Process | GO:0051239 | regulation of multicellular organismal process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.