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Overview

Uniprot ID	A0A8I6AV27
Protein Name	RIMS-binding protein 2
Gene Name	Rimbp2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
838	IIKVYGDKDADGFYR

Function

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B

Protein Sequence

10 MREAAERRQQ 20 LELEHEQALA 30 ILNAKQQEIQ 40 LLQQAQVEAK 50 KEHEGAVQLL 60 ENTLDCMQSK 70 VRELEEKCRV 80 QSEQFNLLSR 90 DLEKFRQHAG 100 SIDLLGSNSV 110 ALLDVPLAPG 120 KPFSQYMNGL 130 ATSIHKGHEG 140 PTGHYSVIGD 150 YIPLSGDKLE 160 SPCVKPSFLL 170 RSSSPRCRFE 180 SEMDDDRSSN 190 KSKHSSSGKV 200 HLCVARYSYN 210 PFDGPNENPE 220 AELPLTAGKY 230 LYVYGDMDED 240 GFYEGELLDG 250 QRGLVPSNFV 260 DFIQDNESRF 270 AGTLGSEQDQ 280 NFLNHSGISL 290 ERDSILHLHS 300 PTQVDSGITD 310 NGGGTLDVNI 320 DDIGEDIVPY 330 PRKITLIKQL 340 AKSVIVGWEP 350 PAVPPGWGTV 360 SSYNVLVDKE 370 TRMSLALGRR 380 TKALIEKLNT 390 AACTYRISVQ 400 CVTSRGNSDE 410 LQCTLLVGKD 420 VVVAPSQLRV 430 DNITQISAQL 440 SWLPTNSNYS 450 HIIFLNEEEL 460 DIVKAARYKY 470 QFFNLRPNMA 480 YKVKVLAQPH 490 QMPWQLPLEQ 500 REKKEACVEF 510 STLPAGPPAP 520 PQDVTVQAGA 530 TTASVQVSWK 540 PPALTPTGLS 550 NGANVTGYGV 560 YAKGQRVAEV 570 IAPTADGAAV 580 ELVRLRSLEA 590 KAVSVRTLSA 600 QGESMDSALA 610 AIPPDLLVPP 620 APHPRTAPPP 630 KPLASDMDTK 640 DLGPHVKVDE 650 SWEQSRPPGP 660 AHGHMLEPPD 670 MHSTGPGRRS 680 PSPSRILPQP 690 QGAPVSTTYH 700 TESSRGSDLS 710 DIMEEDEEEL 720 YSEMQLEDGG 730 RRRPSGTSHN 740 ALKILGNSAL 750 MGRGDRMEHV 760 SRRYSHSGGG 770 PQRHRPMAPS 780 IDEYTGRDHL 790 SPDFYDESET 800 DPGAEELPAR 810 IFVALFDYDP 820 LTMSPNPDAA 830 EEELPFKEGQ 840 IIKVYGDKDA 850 DGFYRGETCA 860 RLGLIPCNMV 870 SEIHADDEEM 880 MDQLLRQGFL 890 PLNTPVEKIE 900 RSRRSGRGHS 910 VPTRRMVALY 920 DYDPRESSPN 930 VDVEAELLFC 940 TGDIITVFGE 950 IDEDGFYYGE 960 LNGQKGLVPS 970 NFLEEVPDDV 980 EVHLSDAPPH 990 YSHDPPMRTK 1000 AKRKKSVHFT P

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0044305	calyx of Held
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.