Overview
| Uniprot ID | A0A8I6AV42 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | Prkacb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 11 |
KEFLAKAKEDFLRKW |
| 267 |
LLQVDLTKRFGNLKN |
| 71 |
KQKVVKLKQIEHTLN |
| 80 |
IEHTLNEKRILQAVE |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MNVKEFLAKA
20
KEDFLRKWEN
30
PPPSNAGLED
40
FERKKTLGTG
50
SFGRVMLVKH
60
KATEQYYAMK
70
ILDKQKVVKL
80
KQIEHTLNEK
90
RILQAVEFPF
100
LVRLEYSFKD
110
NSNLYMVMEY
120
VPGGEMFSHL
130
RRIGRFSEPH
140
ARFYAAQIVL
150
TFEYLHSLDL
160
IYRDLKPENL
170
LIDHQGYIQV
180
TDFGFAKRVK
190
GRTWTLCGTP
200
EYLAPEIILS
210
KGYNKAVDWW
220
ALGVLIYEMA
230
AGYPPFFADQ
240
PIQIYEKIVS
250
GKVRFPSHFS
260
SDLKDLLRNL
270
LQVDLTKRFG
280
NLKNGVSDIK
290
THKWFATTDW
300
IAIYQRKVEA
310
PFIPKFRGSG
320
DTSNFDDYEE
330
EEIRVSITEK
CGKEFCEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
| Biological Process |
GO:0051447 |
negative regulation of meiotic cell cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.