Overview
| Uniprot ID | A0A8I6AVN2 |
|---|
| Protein Name | Syntaxin-1A |
|---|
| Gene Name | Stx1a |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 46 |
EIRGFIDKIAENVEE |
Function
Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1)
Protein Sequence
10
MKDRTQELRT
20
AKDSDDDDDV
30
TVTVDRDRFM
40
DEFFEQVEEI
50
RGFIDKIAEN
60
VEEVKRKHSA
70
ILASPNPDEK
80
TKEELEELMS
90
DIKKTANKVR
100
SKLKSIEQSI
110
EQEEGLNRSS
120
ADLRIRKTQH
130
STLSRKFVEV
140
MSEYNATQSD
150
YRERCKGRIQ
160
RQLEITGRTT
170
TSEELEDMLE
180
SGNPAIFASG
190
IIMDSSISKQ
200
ALSEIETRHS
210
EIIKLENSIR
220
ELHDMFMDMA
230
MLVESQGFAG
240
LERWPQWLRA
250
LTTALTALPE
260
VLGSNPSNHM
VAHNHL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030672 |
synaptic vesicle membrane |
| Biological Process |
GO:0006887 |
exocytosis |
| Biological Process |
GO:0006836 |
neurotransmitter transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.