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Overview

Uniprot IDA0A8I6AVN3
Protein NameLeucine-rich repeat-containing protein 59
Gene NameLrrc59
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
69 KLDLSKNKLQQLPAD

Function

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores

Protein Sequence

10 MTKTGSKGGN 20 LRDKLDGNEL 30 DLSLSDLNEV 40 PVKELVSTIP 50 RALGAHLLLT 60 PSDFCGLTHL 70 VKLDLSKNKL 80 QQLPADFGRL 90 VNLQHLDLLN 100 NRLVTLPVSF 110 AQLKNLKWLD 120 LKDNPLDPVL 130 AKVAGDCLDE 140 KQCKQCANKV 150 LQHMKAVQAD 160 QERERQRRLE 170 VEREAEKKRE 180 AKQQAKEAKE 190 RELRKREKAE 200 EKERRRKEYD 210 AQKASKREQE 220 KKPKKETNQA 230 PKSKSGSRPR 240 KPPPRKHNRS 250 WAVLKGLLLL 260 LLLCVAGGLV 270 VCRVTGLQQQ 280 PLCTSVNAIY 290 DNAVQGLRHH 300 EILQWVLQTD SQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0042645 mitochondrial nucleoid
Cellular Component GO:0005635 nuclear envelope

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.