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Overview

Uniprot ID	A0A8I6AWN6
Protein Name	Epidermal growth factor receptor substrate 15-like 1
Gene Name	Eps15l1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
322	IAQLQREKYSLEQDI
468	DINQARSKLSQLQES

Function

Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2

Protein Sequence

10 MAAPLLPLSQ 20 QIPSGNPLYE 30 SYYKQVDPAY 40 TGRVGASEAA 50 LFLKKSGLSD 60 IVLGKIWDLA 70 DPEGKGFLDK 80 QGFYVALRLV 90 ACAQSGHEVT 100 LSNLGLTMPP 110 PKFHDTSSPL 120 MATQSSAEAH 130 WAVRVEEKAK 140 FDGIFESLLP 150 VNGLLSGDKV 160 KPVLMNSKLP 170 LDVLGRVWDL 180 SDIDKDGHLD 190 RDEFAVPPVA 200 WVVPVADKMR 210 FDEIFLKTDL 220 DLDGYVSGQE 230 VKEIFMHSGL 240 TQNLLAHIWA 250 LADTRQTGKL 260 SKEQFALAMY 270 FIQQKVSKGI 280 DPPQVLSPDM 290 VPPSERGTPI 300 PDSSSALGSG 310 EFTGVKELDD 320 ISQEIAQLQR 330 EKYSLEQDIR 340 EKEEAIRQKA 350 SEVQELQNDL 360 DRETSSLQEL 370 EAQKQDAQDR 380 LDEMDQQKAK 390 LRDMLSDVRQ 400 KCQDETQTIS 410 SLKTQIQSQE 420 SDLKSQEDDL 430 NRAKSELNRL 440 QQEETQLEQS 450 IQAGRAQLET 460 ILRSLKCTQD 470 DINQARSKLS 480 QLQESHLEAH 490 RSLEQYDQVP 500 DGVSGTSLPD 510 LATLNEGILL 520 AERGGFGAMD 530 DPFKNKALLF 540 SNNSQELHPD 550 PFQAEDPFKS 560 DPFKGADPFK 570 GDPFQSDPFS 580 EQQTAVTDPF 590 GGDPFKESDP 600 FHSSTSDDFF 610 KKQTKNDPFT 620 SDPFTKNPSL 630 PSKLDPFESS 640 DPFSSSSISS 650 KGSDPFGTLD 660 PFGSSSFSSA 670 EGFADFSQMS 680 KPPPSGPFSS 690 SLGGTGFSDD 700 PFKSKQDTPA 710 LPPKKPAPPR 720 PKPPSEAAAG 730 QKGSVVYTLL 740 GGQSTPVSQL 750 GSSAFPESPD 760 PFQPLEADSG 770 DPFQNKKGFG 780 DPFSGKDPFA 790 PSSSAKPPKA 800 SSSGFADFTS 810 FGNEEQQLAW 820 AKRESEKAEQ 830 ERLARLRRQE 840 QEDLELAIAL SKADMPA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030132	clathrin coat of coated pit
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0005509	calcium ion binding
Biological Process	GO:0006897	endocytosis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.