Overview
| Uniprot ID | A0A8I6AWW7 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | Capzb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 125 |
ARDKVVGKDYLLCDY |
| 303 |
LNEIYFGKTKDIVNG |
| 320 |
SVQTFADKSKQEALK |
| 322 |
QTFADKSKQEALKND |
| 335 |
NDLVEALKRKQQC** |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MSRRLGTLLS
20
LSHWNSADNL
30
RWTWKHQEIG
40
RWLKSSPGLN
50
CNLWDRWMRR
60
HQGAGCTVLQ
70
GGPLDSNCGS
80
DQQLDCALDL
90
MRRLPPQQIE
100
KNLSDLIDLV
110
PSLCEDLLSS
120
VDQPLKIARD
130
KVVGKDYLLC
140
DYNRDGDSYR
150
SPWSNKYDPP
160
LEDGAMPSAR
170
LRKLEVEANN
180
AFDQYRDLYF
190
EGGVSSVYLW
200
DLDHGFAGVI
210
LIKKAGDGSK
220
KIKGCWDSIH
230
VVEVQEKSSG
240
RTAHYKLTST
250
VMLWLQTNKS
260
GSGTMNLGGS
270
LTRQMEKDET
280
VSDCSPHIAN
290
IGRLVEDMEN
300
KIRSTLNEIY
310
FGKTKDIVNG
320
LRSVQTFADK
330
SKQEALKNDL
340
VEALKRKQQC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.