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Overview

Uniprot IDA0A8I6G8K5
Protein NameGlucosidase 2 subunit beta
Gene NamePrkcsh
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
157 LLELQAGKKSLEDQV

Function

Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia

Protein Sequence

10 MLLLLLLLPL 20 CWAVEVKRPR 30 GVSLSNHHFY 40 DESKPFTCLD 50 GTATIPFDQV 60 NDDYCDCKDG 70 SDEPGTAACP 80 NGSFHCTNTG 90 YKPLYILSSR 100 VNDGVCDCCD 110 GTDEYNSGTV 120 CENTCRWVGT 130 RGAWATLHLG 140 SLCLEVRLLP 150 CPALERQSKL 160 LELQAGKKSL 170 EDQVETLRTA 180 KEEAERPEKE 190 AKDQHRKLWE 200 EQQAAAKARR 210 EQELAASAFQ 220 ELDDNMDGLV 230 SLAELQTHPE 240 LDTDGDGGLS 250 EEEAQALLSG 260 DTQTDTTSFY 270 DRVWAAIRDK 280 YRSEVPPTDI 290 PVPEVTEPKE 300 EKLPVLPPME 310 EEEEEEEPEE 320 EEEEEEEEVP 330 GEQPKEVPPP 340 QQPLRPPSPA 350 EDEKMPPYDE 360 ETQAIIDAAQ 370 EARNKFEEVE 380 RSLKEMEESI 390 RSLEQEISFD 400 FGPSGEFAYL 410 YSQCYELTTN 420 EYVYRLCPFK 430 LVSQKPKHGG 440 SPTSLGTWGS 450 WAGPDDDKFS 460 AMKYEQGTGC 470 WQGPNRSTTV 480 RLLCGKETVV 490 TSTTEPSRCE 500 YLMELMTPAA 510 CPEPPPEVPT DGDHDEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0017177 glucosidase II complex
Molecular Function GO:0005509 calcium ion binding

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.