Search Results
Overview
| Uniprot ID | A0A8I6G8L2 |
|---|---|
| Protein Name | Wiskott-Aldrich syndrome protein family member |
| Gene Name | Wasf3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | INMKKAFKSSTIQDQ |
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex
Protein Sequence
10
MPLVKRNIEP
20
RHLCRGALPE
30
GITSELECVT
40
NSTLAAIIRQ
50
LSSLSKHAED
60
IFGELFNEAN
70
NFYIRANSLQ
80
DRIDRLAVKV
90
TQLDSTVEEV
100
SLQDINMKKA
110
FKSSTIQDQQ
120
VVSKNSIPNP
130
VADIYNQSDK
140
PPPLSILTPY
150
RDDKKDGLKF
160
YTDPSYFFDL
170
WKEKMLQDTE
180
DKRKEKRRQK
190
REKLKLNPSR
200
SQQVYVRKVR
210
TRREEWERRK
220
MGIEFMSDAK
230
RLDQAGSAKE
240
DARPRGSHTS
250
DVTDYSYPAT
260
PNHALQVQPV
270
TPSYTAGDAP
280
LHAATNQGAE
290
HEYRPSSASA
300
RHMALNRPQQ
310
PPPPPPPQAP
320
DGSQASTSVA
330
PADYGMLPAQ
340
IIEYYNPSGP
350
PPPPPPPMIP
360
SAQTAFVSPL
370
QIPAQQPSFP
380
ASTGSTYPTP
390
PHQPSTGLLA
400
TAPPPPGPPP
410
PPPGPPGPSS
420
LSSSPMHGPP
430
VAEAKRPEPA
440
QPPISDARSD
450
LLAAIRMGIQ
460
LKKVQEQREQ
470
EAKREPVGND
480
VATILSRRIA
490
VEYSDSDDDS
EFDENDWSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.