Search Results
Overview
| Uniprot ID | A0A8I6GA62 |
|---|---|
| Protein Name | NSFL1 cofactor p47 |
| Gene Name | Nsfl1c |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 285 | HRDEDFVKPKGAFKA |
Function
Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis
Protein Sequence
10
MAEERQDALR
20
EFVAVTGAEE
30
DRARFFLESA
40
GWDLQIALAS
50
FYEDGGDEDI
60
VTISQATPSS
70
VSRGTAPSDN
80
RVTSFRDLIH
90
DQDEEEEEEE
100
GQSCSWTTRV
110
PGVDILERIF
120
EIGASLASSA
130
SPEAPRVHRK
140
NGRFYAGGSE
150
RSGQQIVGPP
160
RKKSPNELVD
170
DLFKGAKEHG
180
AVAVERVTKS
190
PGETSKPRPF
200
AGGGYRLGAA
210
PEEESAYVAG
220
ERRRHSGQDV
230
HVVLKLWKTG
240
FSLDNGDLRS
250
YQDPSNAQFL
260
ESIRRGEVPA
270
ELRRLAHGGQ
280
VNLDMEDHRD
290
EDFVKPKGAF
300
KAFTGEGQKL
310
GSTAPQVLNT
320
SSPAQQAENE
330
AKASSSILIN
340
EAEPTTNIQI
350
RLADGGRLVQ
360
KFNHSHRISD
370
IRLFIVDARP
380
AMAATSFVLM
390
TTFPNKELAD
400
ENQTLKEANL
410
LNAVIVQRLT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005795 | Golgi stack |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008289 | lipid binding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.