Overview
| Uniprot ID | A0A8I6GAH4 |
|---|
| Protein Name | Protein disulfide-isomerase |
|---|
| Gene Name | Pdia3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 135 |
GIVSHLKKQAGPASV |
| 223 |
LANKFEDKIVAYTEK |
| 230 |
KIVAYTEKKMTSGKI |
| 340 |
IRTAKGEKFVMQEEF |
| 371 |
GNLKRYLKSEPIPET |
Function
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity
Protein Sequence
10
MRFSCLALLP
20
GVALLLASAL
30
LASALLASAS
40
DVLELTDENF
50
ESRVSDTGSA
60
GLMLVEFFAP
70
WCGHCKRLAP
80
EYEAAATRLK
90
GIVPLAKVDC
100
TANTNTCNKY
110
GVSGYPTLKI
120
FRDGEEAGAY
130
DGPRTADGIV
140
SHLKKQAGPA
150
SVPLRTEDEF
160
KKFISDKDAS
170
VVGFFRDLFS
180
DGHSEFLKAA
190
SNLRDNYRFA
200
HTNVESLVKE
210
YDDNGEGITI
220
FRPLHLANKF
230
EDKIVAYTEK
240
KMTSGKIKKF
250
IQESIFGLCP
260
HMTEDNKDLI
270
QGKDLLTAYY
280
DVDYEKNTKG
290
SNYWRNRVMM
300
VAKTFLDAGH
310
KLNFAVASRK
320
TFSHELSDFG
330
LESTTGEIPV
340
VAIRTAKGEK
350
FVMQEEFSRD
360
GKALERFLQE
370
YFDGNLKRYL
380
KSEPIPETNE
390
GPVKVVVAES
400
FDDIVNAEDK
410
DVLIEFYAPW
420
CGHCKNLEPK
430
YKELGEKLSK
440
DPNIVIAKMD
450
ATANDVPSPY
460
EVKGFPTIYF
470
SPANKKLTPK
480
KYEGGRELND
490
FISYLQREAT
500
NPPIIQEEKP
510
KKKKKAQEDL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0042824 |
MHC class I peptide loading complex |
| Cellular Component |
GO:0005790 |
smooth endoplasmic reticulum |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0106222 |
lncRNA binding |
| Molecular Function |
GO:0003756 |
protein disulfide isomerase activity |
| Molecular Function |
GO:0044183 |
protein folding chaperone |
| Molecular Function |
GO:0015035 |
protein-disulfide reductase activity |
| Biological Process |
GO:0002502 |
peptide antigen assembly with MHC class I protein complex |
| Biological Process |
GO:1903334 |
positive regulation of protein folding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.