Overview
| Uniprot ID | A0A8I6GBC1 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | Prkacb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 26 |
KEFLAKAKEDFLRKW |
| 282 |
LLQVDLTKRFGNLKN |
| 86 |
KQKVVKLKQIEHTLN |
| 95 |
IEHTLNEKRILQAVE |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MQGDVRNLLH
20
KGDSKGSLKE
30
FLAKAKEDFL
40
RKWENPPPSN
50
AGLEDFERKK
60
TLGTGSFGRV
70
MLVKHKATEQ
80
YYAMKILDKQ
90
KVVKLKQIEH
100
TLNEKRILQA
110
VEFPFLVRLE
120
YSFKDNSNLY
130
MVMEYVPGGE
140
MFSHLRRIGR
150
FSEPHARFYA
160
AQIVLTFEYL
170
HSLDLIYRDL
180
KPENLLIDHQ
190
GYIQVTDFGF
200
AKRVKGRTWT
210
LCGTPEYLAP
220
EIILSKGYNK
230
AVDWWALGVL
240
IYEMAAGYPP
250
FFADQPIQIY
260
EKIVSGKVRF
270
PSHFSSDLKD
280
LLRNLLQVDL
290
TKRFGNLKNG
300
VSDIKTHKWF
310
ATTDWIAIYQ
320
RKVEAPFIPK
330
FRGSGDTSNF
340
DDYEEEEIRV
350
SITEKCGKEF
CEF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
| Biological Process |
GO:0051447 |
negative regulation of meiotic cell cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.