Search Results
Overview
| Uniprot ID | A0A8I6GBC3 |
|---|---|
| Protein Name | Actin-related protein 2 |
| Gene Name | Actr2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 329 | GDVEKLSKFKIRIED |
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament
Protein Sequence
10
GSTPLWFVKC
20
GYAGSNFPEH
30
IFPALVGRPI
40
IRSTTKVGNI
50
EIKDLMVGDE
60
ASELRSMLEV
70
NYPMENGIVR
80
NWDDMKHLWD
90
YTFGPEKLNI
100
DTRSCKILLT
110
EPPMNPTKNR
120
EKIVEVMFET
130
YQFSGVYVAI
140
QAVLTLYAQG
150
LLTGVVVDSG
160
DGVTHICPVY
170
EGFSLPHLTR
180
RLDIAGRDIT
190
RYLIKLLLLR
200
GYAFNHSADF
210
ETVRMIKEKL
220
CYVGYNIEQE
230
QKLALETTVL
240
VESYTLPDGR
250
IIKVGGERFE
260
APEALFQPHL
270
INVEGVGVAE
280
LLFNTIQAAD
290
IDTRSEFYKH
300
IVLSGGSTMY
310
PGLPSRLERE
320
LKQLYLERVL
330
KGDVEKLSKF
340
KIRIEDPPRR
350
KHMVFLGGAV
360
LADIMKDKDN
370
FWMTRQEYQE
380
KGVRVLEKLG
VTVR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005885 | Arp2/3 protein complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0005524 | ATP binding |
| Biological Process | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.