Overview
| Uniprot ID | A0A8I6GBU6 |
|---|
| Protein Name | - |
|---|
| Gene Name | Hmgb1l2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 90 |
NNTAADDKQPYEKKA |
Function
In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages
Protein Sequence
10
MSAKEKGKFE
20
DMAKADKARY
30
EREMKTYIPP
40
KGETKKKFKD
50
PNAPKRPPSA
60
FFLFCSEYRP
70
KIKGEHPGLS
80
IGDVAKKLGE
90
MWNNTAADDK
100
QPYEKKAAKL
110
KEKYEKDIAA
120
YRAKGKPDAA
130
KKGVVKAEKS
140
KKKKEEEDDE
150
EDEEDEEEEE
160
EEEEEEEEDD
DE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Biological Process |
GO:0006338 |
chromatin remodeling |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.