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Overview

Uniprot IDA0A8I6GCQ8
Protein NameDynamin-3
Gene NameDnm3
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
257 AAMLAERKFFLSHPA
87 YAEFLHCKGKKFTDF

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis

Protein Sequence

10 MGNREMEELI 20 PLVNRLQDAF 30 SALGQSCLLE 40 LPQIAVVGGQ 50 SAGKSSVLEN 60 FVGRDFLPRG 70 SGIVTRRPLV 80 LQLVTSKAEY 90 AEFLHCKGKK 100 FTDFDEVRHE 110 IEAETDRVTG 120 MNKGISSVPI 130 NLRVYSPHVL 140 NLTLIDLPGI 150 TKVPVGDQPP 160 DIEYQIRDMI 170 MQFITRENCL 180 ILAVTPANTD 190 LANSDALKLA 200 KEVDPQGLRT 210 IGVITKLDLM 220 DEGTDARDVL 230 ENKLLPLRRG 240 YVGVVNRSQK 250 DIDGKKDIKA 260 AMLAERKFFL 270 SHPAYRHIAD 280 RMGTPHLQKV 290 LNQQLTNHIR 300 DTLPNFRNKL 310 QGQLLSIEHE 320 VEAFKNFKPE 330 DPTRKTKALL 340 QMVQQFAVDF 350 EKRIEGSGDQ 360 VDTLELSGGA 370 KINRIFHERF 380 PFEIVKMEFN 390 EKELRREISY 400 AIKNIHGIRT 410 GLFTPDMAFE 420 AIVKKQIVKL 430 KGPSLKSVDL 440 VMQELINTVK 450 KCTKRLANFP 460 RLCEETERIV 470 ANHIREREGK 480 TKDQVLLLID 490 IQVSYINTNH 500 EDFIGFAKYV 510 IRKGWLTVSN 520 IGIMKGGSKG 530 YWFVLTAESL 540 SWYKDDEEKE 550 KKYMLPLDNL 560 KVRDVEKGFM 570 SSKHVFALFN 580 TEQRNVYKDY 590 RSLELACDSQ 600 EDVDSWKASL 610 LRAGVYPDKS 620 FTNHSHTEKN 630 GISENFSMDP 640 QLERQVETIR 650 NLVDSYMSII 660 NKCIRDLIPK 670 TIMHLMINNV 680 KDFINSELLA 690 QLYSSEDQNT 700 LMEESVEQAQ 710 RRDEMLRMYQ 720 ALKEALAIIG 730 DINTVTVSTP 740 APPPVDDSWL 750 QHSRRLGKRS 760 PPPSPTTQRR 770 LTLSAPLPRP 780 ASSRGPAPAI 790 PSPGPHSGAP 800 PVPFRPGPLP 810 PFPNSSDSYG 820 APPQVPSRPT RAPPSVPR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005874 microtubule
Cellular Component GO:0043005 neuron projection
Molecular Function GO:0001664 G protein-coupled receptor binding
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0050998 nitric-oxide synthase binding
Molecular Function GO:0120283 protein serine/threonine kinase binding
Biological Process GO:0006897 endocytosis
Biological Process GO:0051130 positive regulation of cellular component organization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.