Search Results
Overview
| Uniprot ID | A0A8I6GDC1 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | Idh3g |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | PGVVTRHKDIDILIV |
| 217 | AQESGRKKVTAVHKA |
| 317 | TATRNTGKSIANKNI |
Function
Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MLIRSLGTAT
20
LPWLACGLVL
30
VGRRELTQAR
40
VHIGVSKGLP
50
SPFPFFQPPS
60
AKYGGRHTVT
70
MIPGDGIGPE
80
LMLHVKSVFR
90
HACVPVDFEE
100
VHVSSNADEE
110
DIRNAIMAIR
120
RNRVALKGNI
130
ETNHNLPPSH
140
KSRNNILRTS
150
LDLYANVIHC
160
KSLPGVVTRH
170
KDIDILIVRE
180
NTEGEYSSLE
190
HESVAGVVES
200
LKIITKAKSL
210
RIAEYAFKLA
220
QESGRKKVTA
230
VHKANIMKLG
240
DGLFLQCCRE
250
VAARYPQITF
260
DSMIVDNTTM
270
QLVSRPQQFD
280
VMVMPNLYGN
290
IVNNVCAGLV
300
GGPGLVAGAN
310
YGHVYAVFET
320
ATRNTGKSIA
330
NKNIANPTAT
340
LLASCMMLDH
350
LKLHSYATSI
360
RKAVLASMDN
370
ENMHTPDIGG
380
QGTTSQAIQD
390
IIRHIRIING
RAVEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.