Overview
| Uniprot ID | A0A8I6GE69 |
|---|
| Protein Name | Proteasome subunit alpha type-6 |
|---|
| Gene Name | Psma6 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 106 |
RYEAANWKYKYGYEI |
| 49 |
TSVAVRGKDCAVIVT |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
HLNLMKIHNI
20
PGPSSTYLEK
30
QQQTCFVFPE
40
YAFKAINQGG
50
LTSVAVRGKD
60
CAVIVTQKKV
70
PDKLLDSSTV
80
THLFKITENI
90
GCVMTGMTAD
100
SRSQVQRARY
110
EAANWKYKYG
120
YEIPVDMLCK
130
RIADISQVYT
140
QNAEMRPLGC
150
CMILIGIDEE
160
QGPQVYKCDP
170
AGYYCGFKAT
180
AAGVKQTEST
190
SFLEKKVKKK
200
FDWTFEQTVE
210
TAITCLSTVL
220
SIDFKPSEIE
230
VGVVTVENPK
240
FRILTEAEID
250
AHLVALAERD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0051603 |
proteolysis involved in protein catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.