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Overview

Uniprot IDA0A8I6GE85
Protein NamePhosphoinositide phospholipase C
Gene NamePlch2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1074 GSSSPRGKAPAGEAT

Function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain

Protein Sequence

10 MGGLAWGPSR 20 AAGSSWVNAS 30 GTWEQSLGWG 40 FRGLQGGRQR 50 DRGEKEIPEE 60 PPCQLPPQLG 70 LSLRALSGSG 80 EQASSYHLDM 90 PGSQLPAAIR 100 TTGAVACLAE 110 VLLWVGGSVV 120 VSPRWQLSLL 130 VERCMSAMQE 140 GTQMVKLRGS 150 SKGLVRFYYL 160 DEHRSCLRWR 170 PSRKNEKAKI 180 SIDSIQEVSE 190 GRQSEIFQRY 200 PDSSFDPNCC 210 FSIYYGSHRE 220 SLDLVSPSSE 230 EARTWVTGLR 240 YLMAGISDED 250 SLARRQRTRD 260 QWLKQTFDEA 270 DKNGDGSLSI 280 SEVLQLLHKL 290 NVNLPRQRVK 300 QMFREADTDD 310 HQGTLGFEEF 320 CAFYKMMSTR 330 RDLYLLMLTY 340 SNHKDHLDAS 350 DLQRFLEVEQ 360 KMSGVTLESC 370 QSIIEQFEPC 380 LENKSKGVLG 390 IDGFTNYTRS 400 PAGDIFNPEH 410 HRVHQDMTQP 420 LSHYFITSSH 430 NTYLVGDQLM 440 SQSRVDMYAW 450 VLQAGCRCVE 460 VDCWDGPDGE 470 PIVHHGYTLT 480 SKILFKDVIE 490 TINKYAFIKN 500 EYPVILSIEN 510 HCSVVQQKKM 520 AQYLTDILGD 530 KLDLSSVSGE 540 DATMLPSPQM 550 LKGKILVKGK 560 KLPANISEDA 570 EEGEVSDEDS 580 ADEIEDDCKL 590 LNGDASTNRK 600 RVENIAKKKL 610 DSLIKESKIR 620 DCEDPNDFTV 630 STLSPSGKLG 640 HKAEAKKAQS 650 KAEEDVESGE 660 DTGVSRRNSR 670 LLMSSFSKRK 680 KKGSKIKKVA 690 SVEEGDESLD 700 SPGSQSRGTA 710 RQKKTMKLSR 720 ALSDLVKYTK 730 SVGTHDVEME 740 VVSSWQVSSF 750 SETKAHQILQ 760 QKPAQYLRFN 770 QHQLSRIYPS 780 SYRVDSSNYN 790 PQPFWNAGCQ 800 MVALNYQSEG 810 RMLQLNRAKF 820 SANGGCGYVL 830 KPQCMCQGVF 840 NPNSEDPLPG 850 QLKKQLALRI 860 ISGQQLPKPR 870 DSVLGDRGEI 880 IDPFVEVEVI 890 GLPVDCSKEQ 900 TRVVDDNGFN 910 PMWEETLVFT 920 VHMPEIALVR 930 FLVWDHDPIG 940 RDFIGQRTLA 950 FSSMMPGYRH 960 VYLEGMEEAS 970 IFVHVAVSDI 980 SGKVKQTLGL 990 KGLFLRGPKP 1000 GSLDSHAAGQ 1010 PLPRPSVSQR 1020 LLRRTASAPT 1030 KSQKPSRKGF 1040 PELALGTQDA 1050 GSEGAADDVA 1060 PPSPNPALEA 1070 PTQERSGSSS 1080 PRGKAPAGEA 1090 TEERTPAQVR 1100 SPRAPEGPGP 1110 AGMAATCMKC 1120 VVGSCTGMDV 1130 EGLRREQQPS 1140 PGPAGSRTAI 1150 SQQPRARVDS 1160 LGGPCCSLSP 1170 RATPGRSREA 1180 PKGPRARRQG 1190 PGGSSVSSDS 1200 SSPDSPGSPK 1210 VAPCQPEGAH 1220 RQQGALQGEM 1230 NALFVQKLEE 1240 IRSHSPMFST VRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0016042 lipid catabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.