Search Results

Overview

Uniprot ID	A0A8I6GEJ7
Protein Name	Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Gene Name	Acsf2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
164	IVFPKQFKTQQYYNI
181	QVCPELEKAQPGALK
322	SPSFNGKKALEAISR
492	CRIVGRSKDMIIRGG
558	IKAFCKGKISHFKIP

Function

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation

Protein Sequence

10 MAVYLGMLRL 20 GRLCVASLGA 30 RGPRTPLSRP 40 WPNSKLQGVR 50 AFSSGMVDCT 60 NPLPIGGLSY 70 IQGHTDSHLV 80 NKTVGECLDA 90 TAQRFPNREA 100 LVIIHENIRL 110 NFAQLKEEVD 120 RAASGLLSIG 130 LRKGDRLGMW 140 GPNSYAWVLI 150 QLATAQAGII 160 LVGCKGIVFP 170 KQFKTQQYYN 180 ILKQVCPELE 190 KAQPGALKSE 200 RLPDLTTVIS 210 VDAPLPGTLL 220 LDEVVAAGGK 230 EQNLAQLRYH 240 QGFLSCYDPI 250 NIQFTSGTTG 260 NPKGATLSHH 270 NIVNNSNLIG 280 QRLKMPAKTA 290 EELRMVLPCP 300 LYHCLGSVGG 310 TMVSVVHGAT 320 LLLSSPSFNG 330 KKALEAISRE 340 KGTLLYGTPT 350 MFVDILNQPD 360 FSSYDFTTIR 370 GGVIAGSLAP 380 PELIRAIISK 390 MNMKELVVVY 400 GTTENSPVTF 410 MNFPEDTLEQ 420 KAGSVGRIMP 430 HTEAQIVNME 440 TGELTKLNMP 450 GELCIRGYCV 460 MQGYWGEPQK 470 TFETVGQDRW 480 YRTGDIASMD 490 EQGFCRIVGR 500 SKDMIIRGGE 510 NIYPAELEDF 520 FHKHPQVQEA 530 QVVGVKDDRM 540 GEEICACIRL 550 KSGETTTEEE 560 IKAFCKGKIS 570 HFKIPRYIVF 580 VEGYPLTVSG 590 KIQKFKLREQ MEQHLKL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0031956	medium-chain fatty acid-CoA ligase activity
Biological Process	GO:0006629	lipid metabolic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.