Overview
| Uniprot ID | A0A8I6GFB3 |
|---|
| Protein Name | F-actin-capping protein subunit beta |
|---|
| Gene Name | Capzb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 114 |
ARDKVVGKDYLLCDY |
| 292 |
LNEIYFGKTKDIVNG |
| 311 |
DAIPDNHKFKQLQRE |
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MAGAGRKVVA
20
ARRGGEGEGG
30
ADPDVHSWAP
40
GEVEAPGPAA
50
GGRATDAGTG
60
TVAAAATMSD
70
QQLDCALDLM
80
RRLPPQQIEK
90
NLSDLIDLVP
100
SLCEDLLSSV
110
DQPLKIARDK
120
VVGKDYLLCD
130
YNRDGDSYRS
140
PWSNKYDPPL
150
EDGAMPSARL
160
RKLEVEANNA
170
FDQYRDLYFE
180
GGVSSVYLWD
190
LDHGFAGVIL
200
IKKAGDGSKK
210
IKGCWDSIHV
220
VEVQEKSSGR
230
TAHYKLTSTV
240
MLWLQTNKSG
250
SGTMNLGGSL
260
TRQMEKDETV
270
SDCSPHIANI
280
GRLVEDMENK
290
IRSTLNEIYF
300
GKTKDIVNGL
310
RSLDAIPDNH
320
KFKQLQRELS
330
QVLTQRQVYI
QPDN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008290 |
F-actin capping protein complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003779 |
actin binding |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0051016 |
barbed-end actin filament capping |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.