Search Results

Overview

Uniprot IDA0A8I6GGJ4
Protein NameReticulon
Gene NameRtn1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
36 EDEEATPKGARPAQQ
364 IAAIKEAKGLSYETT
766 HINTVVAKIQAKIPG
770 VVAKIQAKIPGAKRH

Function

Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity

Protein Sequence

10 MAAPPDLQDE 20 PLSPANPGSQ 30 LFGGRGEGED 40 EEATPKGARP 50 AQQDGEPAWG 60 SGAGAGVVSS 70 RELCSGPARS 80 PPVAMETAST 90 GVAAVPDALD 100 HSSSPTLKDG 110 EGACYTSLIS 120 DICYPPREDS 130 AYFTGILQKE 140 NGHITTSESP 150 EELGTPGPSL 160 PEVPGTEPHG 170 LLSSDSGIEM 180 TPAESTEVNK 190 ILADPLDQMK 200 AEACKYIDIT 210 RPQEAKGQEE 220 QSPGLEDKDL 230 DFKDKDSEVS 240 TKPEGVHAPN 250 QPSPVEGKLI 260 KDNLFEESTF 270 APYIDELSDE 280 QHRMSLVTAP 290 VKITLTEIGP 300 PVMTATHETI 310 PEKQDLCLKP 320 SPDTVPTVTV 330 SEPEDDSPGS 340 VTPPSSGTEP 350 SAAESQGKGS 360 VSEDELIAAI 370 KEAKGLSYET 380 TESPRPVGQA 390 ADRPKVKARS 400 GLPTIPSSLD 410 QEASSAESGD 420 SEIELVSEDP 430 MASEDALPSG 440 YVSFGHVSGP 450 PPSPASPSIQ 460 YSILREEREA 470 ELDSELIIES 480 CDASSASEES 490 PKREQDSPPM 500 KPGVLDAIRE 510 ETSSRATEER 520 APSHQGPVEP 530 DPMLSFTPVT 540 LQSRPEPSSG 550 DGAPVPEPPK 560 SQQQKPEEEA 570 VSSSQSPAAT 580 EIPGPLGSDL 590 VPPLPFFNKQ 600 KAIDLLYWRD 610 IKQTGIVFGS 620 FLLLLFSLTQ 630 FSVVSVVAYL 640 ALAALSATIS 650 FRIYKSVLQA 660 VQKTDEGHPF 670 KAYLELEITL 680 SQEQIQKYTD 690 CLQLYVNSTL 700 KELRRLFLVQ 710 DLVDSLKFAV 720 LMWLLTYVGA 730 LFNGLTLLLM 740 AVVSMFTLPV 750 VYVKHQAQVD 760 QYLGLVRTHI 770 NTVVAKIQAK IPGAKRHAE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0043025 neuronal cell body
Biological Process GO:1902430 negative regulation of amyloid-beta formation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.